Synthesis of diverse (E)‐2‐((1H‐imidazol‐1‐yl)methyl)‐2‐((benzyloxy)methyl)‐2,3‐dihydro‐1H‐inden‐1‐one O‐benzyl oxime derivatives as potent antileishmanial agents

Abstract

A series of (E)-2-((1H-imidazol-1-yl)methyl)-2-((benzyloxy)methyl)-2,3-dihydro-1H-inden-1-one O-benzyl oximes (6a-j) were prepared and evaluated for their in vitro antileishmanial potency against Leishmania donovani (in promastigote and amastigote models). At a concentration of 05-μg/mL, compounds 3a-d, 4a-d, 5a, 5b, 6a-d, and 7a-d exhibited 97% to 100% and 87% to 100% inhibition against promastigotes and amastigotes, respectively. Compounds 6a, 6d-6j and 6a, 6i, 6j exhibited equal antileishmanial potency to that of SSG and Pentamidin at lower values of IC 50 .