Synthesis of Enantiomeric Aminophosphonic Acids and Peptides

Kukhar, V. P.; Solodenko, V. A.; Soloshonok, Vadim A.; Kasheva, T. N.

doi:10.1080/10426509608046315

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1998

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“…As a result, the latter undergo condensation at the terminal carbon atom of the phosphorus reagent. 18,109 Polyfunctional AP can be obtained by functionalisation involving other unsaturated fragments as well. For example, bisphosphonates 19 were synthesised 110 which represent the Diels ± Alder adducts of maleic anhydride with furan derivatives of AP.…”

Section: Other Methodsmentioning

confidence: 99%

The Kabachnik–Fields reaction: synthetic potential and the problem of the mechanism

1998

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The published data of the last decade concerning the mechanism of the Kabachnik ± Fields reaction and its significance for the chemistry of organophosphorus compounds as a method for the synthesis of a-amino phosphonates and their numerous functionally substituted derivatives and analogues, such as phosphinates and phosphine oxides, are generalised and systematised. The review discusses the classical version of the Kabachnik ± Fields reaction, its modifications with the use of phosphorus chlorides, neutral esters and inorganic phosphorus acids, as well as chemical processes simulating separate steps of the reaction, viz., hydrophosphorylation of imines and amination of a-hydroxy phosphonates. Data on the practical application of a-amino phosphonates are presented. The bibliography includes 253 references.

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Section: Other Methodsmentioning

confidence: 99%