“…Additionally, some multi component reactions including C-C bond formation, coupling reaction, Knoevenagel condensation reaction, cycloaddition, dehydration esteri cation has been reported [38,39]. In the last few years, various catalysts have been used for the synthesis of 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives involving three-component condensation reaction between phthalhydrazide, malononitrile, aldehyde such as Fe 3 O 4 @SiO 2 -imine/phenoxy-Cu(II) [7], Fe 3 O 4 @SiO 2 @CPTES@Cu(II)Schiff base complex [40], [Bu 3 NH] [HSO 4 ] [41], agro-waste extract WEMPA [42], (DIPEAc) [43], β-cyclodextrin [44], Na 2 eosin Y [45], 2-AP(2-aminopyridine) [46], CuO NPs [14], Cu(OTf) 2 [47], BW 12 -ILMNPs [48], ZrO 2 NPs [49], nano-PbO [25] and BSA [35].…”