Synthesis of fluorofurans and perfluoroalkylfurans

Synthesis and Properties of Fluoropyrroles and Their Analogues

“…Being interested in the synthesis of organofluorine compounds, we recently presented a detailed overview of methods for the synthesis and applications of α,β-unsaturated trifluoromethyl ketones, 13 trifluoromethyl pyrroles and trifluoromethyl indoles, 14 fluorofurans and perfluoroalkylfurans, 15 and fluorinated thiophenes and their benzo analogues. 16 Herein, we highlight methods for the synthesis of fluoropyrroles, fluoroindoles, and some other condensed anologues of fluoropyrroles ( Figure 2).…”

Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics

“…Both overview of methods for the synthesis of fluorofurans and perfluoroalkylfurans [21]. More general reviews on the preparation of polyfluorinated heterocyclic and heteroaromatic compounds have been compiled by both Brooke and Yakobson [22,23].…”

Electrophilic Cyclizations of 2‐Fluoroalk‐3‐yn‐1‐ones: Room‐Temperature Synthesis of Diversely 2,5‐Disubstituted 3,4‐Fluorohalofurans

“…Indeed, fluorofuran or (perfluoroalkyl)furan fragments have already been embedded within structures possessing important pharmacological properties. [9] Recently, we have reported gold-catalyzed cycloisomerization of 2-fluoroalk-3-yn-1-ones as a tool for the synthesis of unsymmetrically 2,5-disubstituted 3-fluoro-the synthesis of 2,5-disubstituted 3-bromo-4-fluoro-and 3-fluoro-4-iodofurans. The sequential procedure starts at monofluorination of the alk-1-en-3-yn-1-yl silyl ethers with Selectfluor and proceeds with good overall yields (62-78 %).…”