Synthesis of Fused Indoles by Sequential Palladium‐Catalyzed Heck Reaction and N‐Heteroannulation.

Abstract

Two consecutive intramolecular cyclization reactions of alkenyl 2-bromo-3-nitrobenzyl ethers give access to a variety of indoles fused at the 3,4-position with six-, seven-, or eight-membered rings. The sequence can be also performed with analogous amides and a malonic acid derivative. -(SOEDERBERG*, B. C. G.; HUBBARD, J. W.; RECTOR, S. R.; O'NEIL, S. N.; Tetrahedron 61 (2005) 15, 3637-3649; Dep. Chem., W. Va. Univ., Morgantown, WV 26506, USA; Eng.) -Klein 32-125