2022
DOI: 10.3390/gels8120806
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis of Gallic Acid-Loaded Chitosan-Grafted-2-Acrylamido-2-Methylpropane Sulfonic Acid Hydrogels for Oral Controlled Drug Delivery: In Vitro Biodegradation, Antioxidant, and Antibacterial Effects

Abstract: In this study, chitosan (CS) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS)-based hydrogels were formulated by the free radical polymerization technique for the controlled release of gallic acid. Fourier transform infrared spectroscopy (FTIR) confirmed the successful preparation and loading of gallic acid within the hydrogel network. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) confirmed the increased thermal stability of the hydrogels following the crosslinking and polym… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
7
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 16 publications
(11 citation statements)
references
References 54 publications
1
7
0
Order By: Relevance
“…The behavior may result from the protonation of functional groups within AMPS [ 85 ]. The swelling degree of hydrogels increased with the increase in AMPS concentration, possibly as a consequence of AMPS containing a large number of—CONH 2 and—SO 3 OH groups, which combine with water molecules after ionization, increasing the swelling of hydrogels, as was previously observed by other researchers [ 48 ].…”
Section: Resultssupporting
confidence: 73%
See 2 more Smart Citations
“…The behavior may result from the protonation of functional groups within AMPS [ 85 ]. The swelling degree of hydrogels increased with the increase in AMPS concentration, possibly as a consequence of AMPS containing a large number of—CONH 2 and—SO 3 OH groups, which combine with water molecules after ionization, increasing the swelling of hydrogels, as was previously observed by other researchers [ 48 ].…”
Section: Resultssupporting
confidence: 73%
“…Xanthan gum is also a biopolymer that increases the tensile stress and cohesion of bonds, resulting in stronger bonds and an increase in tensile strength [ 76 ]. The hydrogels showed better mechanical properties than the previously reported hydrogels [ 48 , 77 ].…”
Section: Resultsmentioning
confidence: 64%
See 1 more Smart Citation
“…The high water content of hydrogels has a significant impact on their permeability, surface properties, biocompatibility, and mechanical properties. Hydrogels can be manufactured using a variety of chemical processes; they can be prepared through three-dimensional polymerization by polymerizing hydrophilic monomers with crosslinking agents, or they can be prepared by polymerizing hydrophilic polymers directly [ 12 ]. The process of polymerization is usually triggered by compounds that contain free radicals or by the application of radiation, such as gamma, ultraviolet, or electron beams [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Hydrophobic interactions could happen between nonpolar areas of GA or EA and specific amino acid residues within collagen molecules, including proline or hydrophobic clusters. The interaction between hydrophobic binding improves GA or EA affinity and binding to collagen [ 45 ].…”
Section: Resultsmentioning
confidence: 99%