Synthesis of gelatin–PVA adsorbent and its application in the separation of ginkgo flavonol glycosides and terpene lactones

Xu, Min; Shi, Zhijun; Li, Feng; Liu, Juxiang; Shi, Ruizhi; Xu, Mancai; Lu, Yue; He, Binglin

doi:10.1016/s1381-5148(00)00059-6

Cited by 20 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adsorption isotherm and adsorption enthalpy are the two basic aspects for the adsorption. According to the adsorption isotherms, adsorption thermodynamic parameters such as adsorption enthalpy, adsorption free energy, and adsorption entropy can be calculated, and adsorption mechanism can also be deduced [15,16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and adsorption behavior of aniline modified polystyrene resin for phenol in hexane and in aqueous solution

Huang

Liu

et al. 2008

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and adsorption behavior of aniline modified polystyrene resin for phenol in hexane and in aqueous solution

Huang

Liu

et al. 2008

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

“…In contrast, when dried leaves were added to an undigested vegetable capsule and immediately extracted (Table 2), about 30% less AN was recovered compared to undigested dried leaves (Table 2) suggesting that the hydroxymethylcellulose comprising the vegetable capsule added to A. annua partially degrades, binds to, or masks AN. Although it can bind to terpenoid lactones (Xu et al, 2001), gelatin did not seem to affect AN when it was added without digestion. We are not aware of any similar reports regarding terpenoid binding to cellulose to explain the AN losses in the presence of undigested vegetable (cellulosic) capsules.…”

Section: 0 Results and Discussionmentioning

confidence: 98%

Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

Weathers

Jordan

Lasin

et al. 2014

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological Relevance Artemisinin (AN) is produced by Artemisia annua, a medicinal herb long used as a tea infusion in traditional Chinese medicine to treat fever; it is also the key ingredient in current artemisinin-based combination therapies (ACTs) effective in treating malaria. Recently we showed that dried leaves from the whole plant A. annua that produces artemisinin and contains artemisinin-synergistic flavonoids seems to be more effective and less costly than ACT oral malaria therapy; however little is known about how digestion affects release of artemisinin and flavonoids from dried leaves. Material and Methods In the current study we used a simulated digestion system to determine how artemisinin and flavonoids are released prior to absorption into the bloodstream. Various delivery methods and staple foods were combined with dried leaves for digestion in order to investigate their impact on the bioavailability of artemisinin and flavonoids. Digestate was recovered at the end of the oral, gastric, and intestinal stages, separated into solid and liquid fractions, and extracted for measurement of artemisinin and total flavonoids. Results Compared to unencapsulated digested dried leaves, addition of sucrose, various cooking oils, and rice did not reduce the amount of artemisinin released in the intestinal liquid fraction, but the amount of released flavonoids nearly doubled. When dried leaves were encapsulated into either hydroxymethylcellulose or gelatin capsules, there was >50% decrease in released artemisinin but no change in released flavonoids. In the presence of millet or corn meal, the amount of released artemisinin declined, but there was no change in released flavonoids. Use of a mutant A. annua lacking artemisinin showed that the plant matrix is critical in determining how artemisinin is affected during the digestion process. Conclusions This study provides evidence showing how both artemisinin and flavonoids are affected by digestion and dietary components for an orally consumed plant delivered therapeutic and that artemisinin delivered via dried leaves would likely be more bioavailable if provided as a tablet instead of in a capsule.

show abstract

“…In the same way, this adsorbent can not be used to separated FG and TL because of its strong hydrophobic affinity [20]. In order to separate these two components, our research group previously had synthesized an adsorbent with the hydrophilic matrix and amide functional groups [21]. Although this hydrophilic adsorbent successfully separate FG and TL, it is not suitable to be used in the industrial production because of its poor intensity during the adsorption process.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of high selectivity polymeric adsorbent and its application on the separation of ginkgo flavonol glycosides and terpene lactones

Ren

Zhao

Zhang

et al. 2008

Reactive and Functional Polymers

Self Cite

View full text Add to dashboard Cite

Synthesis of gelatin–PVA adsorbent and its application in the separation of ginkgo flavonol glycosides and terpene lactones

Cited by 20 publications

References 15 publications

Synthesis, characterization, and adsorption behavior of aniline modified polystyrene resin for phenol in hexane and in aqueous solution

Synthesis, characterization, and adsorption behavior of aniline modified polystyrene resin for phenol in hexane and in aqueous solution

Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

Synthesis of high selectivity polymeric adsorbent and its application on the separation of ginkgo flavonol glycosides and terpene lactones

Contact Info

Product

Resources

About