Synthesis of glutamic acid/polyvinyl alcohol based hydrogels for controlled drug release: In-vitro characterization and in-vivo evaluation

Suhail, Muhammad; Shih, Chuan-Ming; Liu, Jiayu; Hsieh, Wan-Chu; Lin, Yueh‐Min; Lin, I‐Ling; Wu, Pao‐Chu

doi:10.1016/j.jddst.2022.103715

Cited by 7 publications

(4 citation statements)

References 65 publications

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“…Hydrogel degradation slowed with increasing glutamic acid, polyvinyl alcohol, and acrylic acid concentrations, suggesting that hydrogel networks formed when high hydrogel contents were stable. Similar to in vitro studies, in vivo studies have shown that the created hydrogels can release their drugs slowly over time, making them a viable controlled DDS [56].…”

Section: Hydrogel-based Controlled and Extended-release Systemsmentioning

confidence: 94%

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

et al. 2022

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Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.

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Section: Hydrogel-based Controlled and Extended-release Systemsmentioning

confidence: 94%

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

et al. 2022

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“…[ 119 ] By far, the most widely used stimuli‐responsive hydrogels are pH‐sensitive hydrogels. [ 120 ] These types hydrogels usually include at least one kind of polyelectrolyte within the network. With the variation in pH significantly influencing the molecular interactions like hydrogen bonding and electrostatic forces in the hydrogels, [ 121 ] these “smart” or “intelligent” hydrogels will swell and deswell at specific pH, whereby prolong the protection of drugs in stomach or intestine, and dictate the release process.…”

Section: High‐swelling Hydrogelsmentioning

confidence: 99%

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Feng

Wang

2023

Advanced Science

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Hydrogels with tailor‐made swelling‐shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with high swelling capacity have been widely applicated in full‐thickness skin wound healing and tissue regeneration, and drug delivery. Nevertheless, in the fields of tissue adhesives and internal soft‐tissue wound healing, and bioelectronics, non‐swelling hydrogels play very important functions owing to their stable macroscopic dimension and physical performance in physiological environment. Moreover, the negative swelling behavior (i.e., shrinkage) of hydrogels can be exploited to drive noninvasive wound closure, and achieve resolution enhancement of hydrogel scaffolds. In addition, it can help push out the entrapped drugs, thus promote drug release. However, there still has not been a general review of the constructions and biomedical applications of hydrogels from the viewpoint of swelling‐shrinkable properties. Therefore, this review summarizes the tactics employed so far in tailoring the swelling‐shrinkable properties of hydrogels and their biomedical applications. And a relatively comprehensive understanding of the current progress and future challenge of the hydrogels with different swelling‐shrinkable features is provided for potential clinical translations.

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“…In today's scenario, PVA hydrogels are being explored with or without the addition of other polymer composites and polymeric nanoparticles by loading different categories of drugs and validating them for the treatment of various infections [10][11][12] . PVA-based hydrogels are recognized widely as they could be fabricated with the required stability, swelling index, and drug release pattern [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Polymer-based dual drug delivery system for targeted treatment of fluoroquinolone-resistant Staphylococcus aureus mediated infections

Thamilselvan

David

Sajeevan

et al. 2023

Preprint

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The present study attempts to treat S. aureus-induced soft skin infections using a novel combinatorial therapy with an antibiotic, Ciprofloxacin (CIP), and an efflux pump inhibitor 5-Nitro-2-(3-phenylpropoxy) pyridine (5-NPPP) through a smart hydrogel delivery system. The study aims to reduce the increasing rates of infections and antimicrobial resistance; therefore, a novel efflux pump inhibitor molecule is synthesised and delivered along with an antibiotic to re-sensitize the pathogen towards antibiotics and treat the infections. CIP loaded polyvinyl alcohol (PVA) hydrogels at varying concentrations were fabricated and optimized by a chemical cross-linking process, which exhibited sustained release of the drug for 5 days. The compound 5-NPPP loaded hydrogels provided linear drug release for 2 days, necessitating the need for the development of polymeric nanoparticles to alter the release drug pattern. 5-NPPP loaded Eudragit RSPO nanoparticles were prepared by modified nanoprecipitation - solvent evaporation method, which showed optimum average particle size of 230–280 nm with > 90% drug entrapment efficiency. The 5-NPPP polymeric nanoparticles loaded PVA hydrogels were fabricated to provide a predetermined sustained release of the compound to provide synergistic effect. The selected 7% PVA hydrogels loaded with the dual drugs were evaluated using Balb/c mice models induced with S. aureus soft skin infections. The results of in vivo studies were evidenced that the dual drugs loaded hydrogels were non-toxic and reduced the bacterial load causing re-sensitization towards antibiotics, which could initiate re-epithelization. Overall, the research concluded that the PVA hydrogels loaded with CIP and 5-NPPP nanoparticles could be an ideal and promising drug delivery system to treat S. aureus induced skin infections.

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Synthesis of glutamic acid/polyvinyl alcohol based hydrogels for controlled drug release: In-vitro characterization and in-vivo evaluation

Cited by 7 publications

References 65 publications

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Polymer-based dual drug delivery system for targeted treatment of fluoroquinolone-resistant Staphylococcus aureus mediated infections

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