Synthesis of Hetero‐Polymer Functionalized Nanocarriers by Combining Surface‐Initiated ATRP and RAFT Polymerization

Huang, Xin; Hauptmann, Nicole; Appelhans, Dietmar; Formánek, Petr; Simon, Frank; Kaskel, Stefan; Temme, Achim; Voit, Brigitte

doi:10.1002/smll.201201397

Cited by 46 publications

(52 citation statements)

References 48 publications

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“…Huang et al 122 demonstrated that by fabricating smart bi-functionalising MSNs with two pH-dependent polymer types (poly(2-diethylaminoethyl methacrylate) (PDEAEMA)), controlled release of doxorubicin was possible.…”

Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which can deliver therapeutic agents to the target site in a controlled manner. Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent because silica possesses favourable chemical properties, thermal stability and biocompatibility. Currently, sol-gel-derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. Active surface enables functionalisation to modify surface properties and link therapeutic molecules. The tuneable mesopore structure and modifiable surface of mesoporous silica nanoparticle allow incorporation of various classes of drug molecules and controlled delivery to the target sites. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles.

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Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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“…Thus, it is reasonable to presume that, after drying, the dendront ightly congregates on the surface of the material, thus preventing penetration of nitrogen. [42,43] Therefore, the functionalised MSNs-G3 materiali nherits the mesoporouss tructure of the MSNs, and because the dendrons are not stiff and static entities, the material would still preserve the potential to act as ad rug carrier by using the void mesopores.…”

Section: Dendrong Rafting To Mesoporous Silicamentioning

confidence: 99%

Mesoporous Silica Nanoparticles Decorated with Carbosilane Dendrons as New Non‐viral Oligonucleotide Delivery Carriers

Martínez

Fuentes‐Paniagua

Baeza

et al. 2015

Chemistry A European J

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A novel nanosystem based on mesoporous silica nanoparticles covered with carbosilane dendrons grafted on their external surface is reported. This system is able to transport single oligonucleotide strands into cells, avoiding the electrostatic repulsion between the cell membrane and the negatively charged nucleic acids thanks to the cationic charge provided by the dendron coating in physiological conditions. Moreover, the presence of the highly ordered pore network inside the silica matrix would make possible to allocate other therapeutic agents within the mesopores with the aim of achieving a double delivery. First, carbosilane dendrons of second and third generation possessing ammonium or tertiary amine groups as peripheral functional groups were prepared. Hence, different strategies were tested in order to obtain their suitable grafting on the nanoparticles outer surface. As nucleic acid model, a single stranded DNA oligonucleotide tagged with a fluorescent Cy3 moiety was used to evaluate the DNA adsorption capacity. The hybrid material functionalized with the third generation of neutral dendron showed excellent DNA binding properties. Finally, the cytotoxicity as well as the capability to deliver DNA into cells, was tested in vitro using a human osteoblast-like cell line, achieving good levels of internalization of the vector DNA/carbosilane dendron functionalized material without affecting cellular viability.

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“…24 Since then, many MCM-41-based nanoparticles have been developed, most of them including different molecules attached on MSNs surface acting as specific stimuli-responsive gates, thus allowing "zero premature release" and delivery only upon application of a specific stimulus. 25,26,27 These concepts have allowed researchers to design on-command delivery carriers that can be triggered by stimuli such as changes in pH, [28][29][30][31][32][33][34][35][36][37] light, 38-45 temperature [46][47][48][49][50] or ultrasound, 51,52 and the presence of given enzymes 53,54 or of complementary oligonucleotides. [55][56][57][58] In particular, the enzymatic degradation of gatekeepers in MSNs represents an interesting way to achieve controlled release of drugs in target cells.…”

Section: Introductionmentioning

confidence: 99%

Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

et al. 2016

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Mesoporous silica nanoparticles (MSNs) are highly attractive as supports in the design of controlled delivery systems that can act as containers for the encapsulation of therapeutic agents, overcoming common issues such as poor water solubility and poor stability of some drugs and also enhancing their bioavailability. In this context, we describe herein the development of polyglutamic acid (PGA)-capped MSNs that can selectively deliver rhodamine B and doxorubicin. PGA-capped MSNs remain closed in an aqueous environment, yet they are able to deliver the cargo in the presence of pronase because of the hydrolysis of the peptide bonds in PGA. The prepared solids released less than 20% of the cargo in 1 day in water, whereas they were able to reach 90% of the maximum release of the entrapped guest in ca. 5 h in the presence of pronase. Studies of the PGA-capped nanoparticles with SK-BR-3 breast cancer cells were also undertaken. Rhodamine-loaded nanoparticles were not toxic, whereas doxorubicin-loaded nanoparticles were able to efficiently kill more than 90% of the cancer cells at a concentration of 100 μg/mL.

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Synthesis of Hetero‐Polymer Functionalized Nanocarriers by Combining Surface‐Initiated ATRP and RAFT Polymerization

Cited by 46 publications

References 48 publications

Silica-based mesoporous nanoparticles for controlled drug delivery

Silica-based mesoporous nanoparticles for controlled drug delivery

Mesoporous Silica Nanoparticles Decorated with Carbosilane Dendrons as New Non‐viral Oligonucleotide Delivery Carriers

Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

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