Synthesis of Heterobicyclic Nitrogen Systems Bearing a 1,2,4-Triazine Moiety as Anticancer Drugs: Part IV

Synthesis of Some More New Fluorinated 1,2,4-triazino[3,4-b][1,3,4]Thiadiazolonesand Their Molluscicidal Against Selective Snails - Part I

“…5). A recent investigation [1,2], which combines these two biological rings together to give a compact and planner system of 1,2,4-triazino-1,3,4-thidiazolones in hope to enhance that biocidal properties. Thus, alkylation of 5-hydrazino-thiadiazole 5 using both monochloro-acetic acid and/or 1,1-dichloroacetic acid in boiling DMF (via SN 2 reaction) produced …”

“… Functionally 1,2,4-triazines possess important pharmacological, medical agents, as anti HIV [1], antitumor [2], anti-inflammatory [3] and as molluscicidal agents [4], as well as in agriculture field as heribicides [5], Cellobise activity [6] and forms a type of more oxidation states of metal-complexes [7,8].…”

Synthesis of Novel a-Amino Acids Bearing 1,2,4-triazinone and Steroidal Moieties as Enzymetic Affect (Cellobiase Activity) Part I

“…The 6-(2'-aminophenyl)-3-thioxo-1,2,4-triazin-5-ones derivatives showed biological and medicinal activities (Zhang, Wang & Liu, 2012), on tumors (Abdel-Rahman, 1992Abdel-Mpnem & Abdel-Rahman, 2006) and HIV (Abdel-Rahman, 1991;Abdel-Rahman, Morsy, Hnafy & Amene, 1999;El-Gendy, Morsy, Allimony, Abdel-Monem & Abdel-Rahman, 2001 ). In addition, it can have an amylolytic effect (Abdel-Rahman & Abdel-Malik, 1990) and effect antimicrobial agents (Ebraheem et al, 2008;Abdel-Rahman & Ali, 2013).…”

Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety

“…Various 1,2,4-triazine derivatives found application as pharmaceuticals, herbicides, pesticides and dyes [1][2][3][4][5]. Moreover, in recent years, 1,2,4-triazine compounds have been reported to possess biological activities as anti-AIDS [6], anticancer [7], anti-inflammatory [8], antihypertensive activities [9] and antimicrobial activities [10][11].…”