Synthesis of heterobifunctional poly(ethylene glycol)s by an acetal protection method

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation

“…A related initiator with an acid cleavable acetal group was used to prepare polyethers with a predefined, cleavable functionality. , When preparing PEG with this initiator, PEGs with adjustable degree of polymerization with labile acetal unit in the chain are accessible. In particular, this initiator enables the synthesis of cleavable PEG, as shown in Figure .…”

Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm

“…PEG was first modified by introduction of an azide on one terminal group (Scheme 1). Synthetic strategies aimed to asymmetrically modify PEG are largely explored in the literature.In general, the reported methods suffers from a complex chemistry and/or low purity of the final product (Li and Chau, 2010;Szekely et al, 2014). The most common way to synthesize heterotelechelic PEG remains polymerization of ethylene oxide from different initiators (Cammas et al, 1995;Hiki and Kataoka, 2007;Ishii et al, 2005;Raynaud et al, 2009;Thompson et al, 2008).…”

Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

“…1 The most common route to these hetero-bifunctional PEG relies on anionic polymerization of ethylene oxide from functional initiators followed by post-modification of the terminal hydroxyl group. [9][10][11][12][13][14] Other techniques include the modification of commercially available, but expensive, modified PEG molecules [15][16][17] or the sequential and unsymmetrical alteration of end hydroxyl groups of linear PEG. In particular, the use of tosylate activating groups was reported by Mahou and Wandrey 18 for the generation of diverse heterotelechelic PEG oligomers.…”