Synthesis of Heterocyclic Analogs of α‐aminoadipic Acid and its Esters Based on Imidazo[2,1‐<i>b</i>][1,3]Thiazole

Šačkus, Algirdas; Bričkutė, Diana; Paliulis, O.; Sløk, Frank A.

doi:10.1002/jhet.2090

Cited by 5 publications

(1 citation statement)

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“…Algirdas and co-workers established a method for the synthesis of imidazo[2,1-b]thiazoles and ethyl 6-methylimidazo [2,1-b]thiazoles (82) by the reaction of 2-aminothiazole (3) with 2-chloroacetoacetate (79). [52] The product then undergoes free radical bromination reaction with N-bromosuccinimide (NBS) in the presence of benzoyl peroxide to obtain 6-bromomethyl imidazo [ A novel and efficient synthesis of benzo[d]imidazothiazole (91) via copper-promoted cycloaddition was developed by Wang et al [53] α-Methylenyl isocyanides (90) and benzothiazoles (89) were the employed starting materials and the reaction was carried out using 1.5 equiv. copper acetate (Cu (OAc) 2 ) and 1.0 equiv.…”

Section: M Afsina Abdulla Was Born Inmentioning

confidence: 99%

Synthesis and Applications of Imidazothiazoles: An Overview

et al. 2020

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Imidazothiazoles and its derivatives have vital role in medicinal chemistry as they exhibit biological activities such as anti‐tumor, anti‐cancer, anti‐inflammatory, antibacterial, analgesic etc. This review summarises the various methodologies used to synthesise imidazothiazoles, its derivatives and applications covering literature upto 2020 and it emphasizes the synthesis of imidazothiazoles from 2‐aminothiazole, mercaptoimidazole and imidazothiadiazole.

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Section: M Afsina Abdulla Was Born Inmentioning

confidence: 99%