Synthesis of heterocyclic compounds based on oxamic acid monothiooxamides and thiohydrazides

Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

“…Here, we summarize our achievements in the synthesis of heterocyclic derivatives of steroids based on oxamic acid thiohydrazides as polyheteroatom reagents. These reagents are readily available from α-chloroacetamides [20], and enable various five-and six-membered N,O-and S-heterocycles' construction [21][22][23][24][25][26]. The use of oxamic acid thiohydrazides as a reagent for the modification of steroids has never been systematically analyzed.…”