2009
DOI: 10.1021/ja9051125
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Synthesis of Highly Antibacterial Nanocrystalline Trivalent Silver Polydiguanide

Abstract: Highly monodispersed nanoparticles of a trivalent silver polydiguanide complex are synthesized by oxidation of the monovalent silver, followed by stabilization of the oxidized higher-valent metal through complexation with a polydiguanide ligand in a reverse microemulsion at room temperature. The synthesized nanoparticles have excellent photostability and displayed superior antibacterial activity toward Gram-positive and Gram-negative prokaryotes of clinical interest in vitro compared to silver sulfadiazine. Th… Show more

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Cited by 77 publications
(56 citation statements)
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“…We have previously reported the synthesis of high-valence silver nanoconjugates with higher antibacterial efficacy [20,21]. The polydiguanide type compound chlorhexidine (CHX) possessed two ionizable guanidine moieties which were suitable for the synthesis of stable high-valence silver chlorhexidine (Ag-CHX) complex.…”
Section: Synthesis Of Agnps and Ag(ii)pro Nanoparticlesmentioning
confidence: 99%
See 2 more Smart Citations
“…We have previously reported the synthesis of high-valence silver nanoconjugates with higher antibacterial efficacy [20,21]. The polydiguanide type compound chlorhexidine (CHX) possessed two ionizable guanidine moieties which were suitable for the synthesis of stable high-valence silver chlorhexidine (Ag-CHX) complex.…”
Section: Synthesis Of Agnps and Ag(ii)pro Nanoparticlesmentioning
confidence: 99%
“…The Ag 3d 3/2 and Ag 3d 5/2 XPS peaks were observed at 373.40 eV and 367.90 eV, respectively, this was confirmed with literature values for Ag 2+ . We have synthesized the high-valence Ag(II)PRO nanoparticles by a previously published method from our group [20,21]. The 20 nm size of the Ag(II)PRO nanoparticles was achieved by altering the water-to-surfactant molar ratio (R).…”
Section: Synthesis Of Agnps and Ag(ii)pro Nanoparticlesmentioning
confidence: 99%
See 1 more Smart Citation
“…Topical cream containing the AgSD is currently commercially available. In many studies regarding the antibacterial properties of silver and silver nanoparticles, silver sulfadiazine is considered the gold standard and is used to compare the potency of the bactericidal activity of novel substances [17]. By first understanding the mechanism of action of the antibacterial activity of silver at a molecular level, the compound can be improved upon by not only decreasing its size, but also by carrying out modifications that result in synergism.…”
Section: That Agmentioning
confidence: 99%
“…4 The synthesis sequence for silver chlorhexidine nanoparticles in a reverse microemulsion. Reprinted with permission from Pal et al [17].…”
Section: Enhancing the Bactericidal Efficiency Of Agnpsmentioning
confidence: 99%