Synthesis of highly stable pure-silica thin-walled hexagonally ordered mesoporous material

Abstract

Hexagonally ordered mesoporous silica with a very narrow mesopore size distribution and exceptionally high stability paired with unusually thin pore walls was prepared using piperidine and cetyltrimethylammonium bromide.

Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: Influence of pressure on the structure and drug release

“…OMS exhibits good hydrothermal and chemical stability. 6,7 The large pore volume (ca. 1000 mL/g) in combination with the large specific surface area (ca.…”

Preparation of a push–pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core–shell structure

“…32 To our knowledge, investigations into PPOP have mainly 33 focused on how to control the drug release, while ignoring the Mesoporous silica material (MSM) was first discovered by the 42 Mobil Corporation (Kresge et al, 1992) and it has attracted 43 substantial attention from researchers involved in many fields 44 such as nonlinear optics, catalysis, and molecular adsorption. MSM 45 have many excellent properties including good biocompatibility chemical stability (Verlooy et al, 2009 Step 1: 180 mL ethanol, 65 mL deionized water, and 4.5 mL 96 ammonia were placed in a glass container and stirred until 97 uniformly mixed. Then, 15 mL TEOS was dripped into the mixture.…”

Potential of Ordered Mesoporous Silica for Oral Delivery of Poorly Soluble Drugs

“…The OMS material, COK-11, developed by Verlooy et al revealed a superior stability at barely 0.9 nm wall thickness owing to a stronger condensation of the silicate units revealed with 29 Si nuclear magnetic resonance (NMR). Hydrothermal stability was determined by heating a suspension of OMS material in deionized water at 373 K for 24 h. Results show that the hydrothermal as well as the thermal stability along with durability of COK-11 were superior to MCM-41 and comparable to those of the best thick-walled OMS [14].…”

“…Mellaerts et al were the first to demonstrate bioequivalency of OMS to the marketed solid dispersion product, Sporanox ® , using itraconazole loaded into Santa Barbara Amorphous (SBA-15) [12]. Furthermore, studies reporting good thermal and hydro thermal stability and providing additional promising findings drove development for this innovative drug-delivery technology [13,14].…”