2014
DOI: 10.6023/a14110820
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Synthesis of Highly-strained Cyclic Tetrapeptides via Peptide Hydrazide Based Ligation

Abstract: A series of highly-strained cyclic tetrapeptides were efficiently synthesized via peptide hydrazide based ligation, reported by Liu et al. Upon mild oxidative activation, the peptide hydrazide was transformed into a highly active peptide azide intermediate and then in situ converted into a peptide 4-mercaptophenylacetic acid (MPAA) thiol ester, which underwent native chemical ligation (NCL)-mediated cyclization to afford the desired cyclic tetrapeptides. After radical desulfurization, the product with alanine … Show more

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Cited by 5 publications
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