Synthesis of Highly Substituted Pyrrole and Dihydro‐1H‐Pyrrole Containing Barbituric Acids via Catalyst‐Free One‐Pot Four‐Component Reactions

Abstract

A new one‐pot, four‐component reaction of phenylglyoxal or ethylglyoxalate, 1,3‐dicarbonyls, N,N‐dimethylbarbituric acid, and aromatic amines for the synthesis of highly substituted pyrroles or dihydro‐1H‐pyrrole containing barbituric acid in moderate‐to‐good yields is described. Short reaction time, mild reaction condition, use of simple experimental procedure, and prompt isolation of the products are some advantages of this protocol.

A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles

“…The products are obtained in good yields. 94 This reaction was performed for 1-12 h at reflux temperature. The pathway for the synthesis involves a Knoevenagel condensation and intramolecular cyclization leading to the formation of pyrrole derivative.…”