Synthesis of hydrolytically stable low elastic modulus polyurethane-urea for biomedical applications

Jayabalan, M.; Lizymol, P. P.; Thomas, Vinoy

doi:10.1002/(sici)1097-0126(200001)49:1<88::aid-pi298>3.0.co;2-7

Cited by 37 publications

(28 citation statements)

References 18 publications

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“…38 Due to a large difference in surface free energy between the two segments, the polyol soft segment may be enriched at the air-solid interface. 39 The difference in weight loss can be explained by considering the concentration of nano-particles. Based on these results, it is assumed that mainly the degradation is from polymer components because the solubility of calcium phosphate based particles in water is low.…”

Section: Weight Loss Measurementmentioning

confidence: 99%

Synthesis and <I>In-Vitro</I> Analysis of Degradative Resistance of a Novel Bioactive Composite

Khan¹,

Aziz²,

Paul³

et al. 2008

j bionanosci

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The biostability of the polymer is one of the critical parameter to use them for biomaterial application. Polyurethane being one of the most compliant polymer but there are concerns regarding its resistance to degradation, particularly from hydrolysis and oxidation. The aim of this study is to synthesise a novel bioactive composite by creating a covalent linkage between polyurethane and nano-apatites and to analyse the in-vitro hydrolytic degradation of a series of newly synthesised polyurethane (PU) and polyurethane/nano-hydroxyapatite (PU/n-HA) composites. Nanoapatite powder was produced through sol-gel technique. A novel polyurethane composite material was prepared by chemically bonding the n-HA to the diisocyanate component in the polyurethane backbone by utilising solvent polymerisation. The concentration of nano-apatite was 5, 10, 15 and 20% wt/wt in polyurethane. Hydrolytic degradation of the PU and PU/n-HA composites were carried out both in deionised water and in phosphate buffer solution (PBS) having (pH 7.4) at 37 C for a predetermined time interval of 90 days. The PU and PU/n-HA composites were physically and chemically characterised by using contact angle measurement, weight loss, Fourier Transform Infrared spectroscopy couples with Photoacoustic Sampling Cell (FTIR-PAS), Raman Spectroscopy, X-ray Diffraction (XRD) and Scanning electron microscopy (SEM). These characterisations showed that with the addition of n-HA the composite exhibits hydrophobic behaviour and degradation rate reduces due to covalent linkage between n-HA and PU. Hence it has been concluded that the degradation rate of the newly developed PU/n-HA composites can be controlled, which helps in tailor making the biomaterial for specific applications.

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Section: Weight Loss Measurementmentioning

confidence: 99%

Synthesis and <I>In-Vitro</I> Analysis of Degradative Resistance of a Novel Bioactive Composite

Khan¹,

Aziz²,

Paul³

et al. 2008

j bionanosci

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“…27,28 The new polymers were analysed by Fourier transform infraredattenuated total reflectance (FTIR-ATR) spectral studies. The clean polymer film was sandwiched between KRS-5 ATR crystals and the spectrum was recorded.…”

Section: Characterization Of Polymersmentioning

confidence: 99%

“…21 The reduced platelet adhesion and deformation is attributed to greater microphase separation, resulting from a three-dimensional network of hydrogen bonding. Jayabalan et al [22][23][24][25][26][27] have synthesized aliphatic polyurethanes and polyurethane ureas for various biomedical applications. The goal was to develop low modulus and high flex life polyurethanes that can resist degradation for dynamic blood contact applications.…”

Section: Introductionmentioning

confidence: 99%

Studies on the effect of virtual crosslinking on the hydrolytic stability of novel aliphatic polyurethane ureas for blood contact applications

Thomas

Jayabalan

2001

J. Biomed. Mater. Res.

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The effect of virtual crosslinking on the hydrolytic stability of completely aliphatic novel poly(urethane ureas), HFL9-PU1 (hard-segment content 57.5%) and HFL13-PU2 (hard-segment content 67.9%) based on 4,4'-methylene bis(cyclohexyl isocyanate) (H(12)MDI)-hydroxy-terminated polybutadiene-1,6-hexamethylene diamine, was studied. Fourier transform infrared-attenuated total reflectance and wide-angle X-ray diffraction studies revealed hydrogen-bonding interaction and microphase separation and formation of crystallites by short- and long-range ordering in hard-segment domains. Three-dimensional networks from hydrogen bonding in the present polymers lead to virtually crosslinking and insolubility. These polymers were noncytotoxic to L929 fibroblast cells. The hemolytic potential is below the accepted limit. The studies on in vitro biostability in Ringer's solution, phosphate buffered saline, and papain enzyme revealed no weight loss. The infrared spectral studies revealed changes in the surface, especially on HFL9-PU1 aged in Ringer's solution and phosphate buffered saline, and no changes when aged in papain. The marginal changes noticed in tensile properties were attributed to the changes in degree of hydrogen bonding and associated rearrangement of molecular structure in the bulk. The results revealed that the lesser the crosslinking in virgin polymer, the higher the crosslinking in aged polymer and vice versa. Increased crosslinking during aging provided increased tensile properties in the aged polymer over the virgin polymer and vice versa. For comparison, an aliphatic polyetherurethane urea (HFL16-PU3) was also synthesized using poly(oxy tetra methylene glycol) in addition to the above reactants. Though both HFL9-PU1 and HFL16-PU3 contained the same hard-segment content, the aged sample of the latter showed decreased tensile properties with increased crosslinking during aging in contrast to the former. This was attributed to less microphase separation in the virgin HFL16-PU3 polymer.

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“…This high hydrolysis resistance can be a disadvantage in those applications where self-destructive material is desirable. In particular, it refers the use of PUs in biomedicine, due to their very good biocompatibility [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Linear polyurethanes with imidazoquinazoline rings: preparation and properties evaluation

et al. 2019

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In this work, research concerning the synthesis and properties of linear polyurethanes (PUs) with the imidazoquinazoline rings was represented. Reaction conditions of 2,6-bis(2-hydroxyethyl)-1-phenylimida-zo[1,5-c]quinazoline-3,5-dione (BHPIQ) with 1,6-hexamethylene diisocyanate were determined and optimized. These conditions are adapted to reaction of BHPIQ with 4,4′-diphenylmethane diisocyanate and 2,4-toluene diisocyanate. New PUs with imidazoquinazoline rings were characterized by spectral methods (1 H-NMR and IR spectroscopies), which confirm their structures. Their molar masses and dispersity index were measured by size exclusion chromatography method. The wide-angle X-ray scattering and differential scanning calorimetry (DSC) studies have shown that all PUs based on BHPIQ are amorphous. Moreover, thermal properties of PUs were investigated by thermogravimetry analysis, standard DSC, and temperature-modulated DSC methods. During thermogravimetric measurements, the exhaust gases were analyzed by FTIR method. Incorporation of imidazoquinazoline ring into the PU chains escalates their glass transition temperature; thus, their heat resistance was enhanced. Furthermore, their degradation rate and the amount of released degradation products were

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Synthesis of hydrolytically stable low elastic modulus polyurethane-urea for biomedical applications

Cited by 37 publications

References 18 publications

Synthesis and <I>In-Vitro</I> Analysis of Degradative Resistance of a Novel Bioactive Composite

Synthesis and <I>In-Vitro</I> Analysis of Degradative Resistance of a Novel Bioactive Composite

Studies on the effect of virtual crosslinking on the hydrolytic stability of novel aliphatic polyurethane ureas for blood contact applications

Linear polyurethanes with imidazoquinazoline rings: preparation and properties evaluation

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