Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Xidaki, Despoina; Agrafioti, Panagiota; Diomatari, Dimitra; Kaminari, Archontia; Tsalavoutas-Psarras, Eleftherios; Alexiou, Panagiotis; Psycharis, Vassilis; Tsilibary, Effie C.; Silvestros, Spyridon; Sagnou, Marina

doi:10.3390/ma11040595

Cited by 54 publications

(29 citation statements)

References 44 publications

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“…[16,17,18]. Hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP), and biphasic calcium phosphates (BCP, mixtures of HA and β-TCP in a variety of ratios) are the most widely used CaP compounds [19]. HA is the major component of mammalian hard tissues and its synthetic forms are extensively utilized in a large spectrum of bio-applications [20].…”

Section: Introductionmentioning

confidence: 99%

“…β-TCP can be prepared by means of the solid-state reaction of acidic CaPO 4 , e.g., dicalcium phosphate anhydrous, with a base, e.g., CaO [23,24,25,26], or wet chemical methods [19,27,28,29,30], both of which need to be followed by a heat treatment as β-TCP is a high-temperature phase. In wet-chemical processes, β-TCP cannot be directly precipitated, but can be transformed from a non-stoichiometric apatite, which has a molar ratio of Ca/P ranging from 1.33 to 1.65 [20,22] during heat treatment.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles

Bakan

2019

Materials

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The formation of β-tricalcium phosphate (β-TCP) nanoparticles via a wet precipitation technique was studied in a systematical way, taking reaction pH and sintering temperature parameters into account. A full transformation of Ca-deficient hydroxyapatite (CDHA) to β-TCP at 750 °C in under 3 h from Ca++ and PO43− precursor solutions prepared under a pH of 5.5 was observed. For pH values higher than 6.5, CDHA can only partially transform into β-TCP and only at temperatures higher than 750 °C confirmed using X-Ray diffraction and Raman spectroscopy. The morphologies of the particles were also examined by Transmission electron microscopy. The lower temperatures and the shorter sintering time allow for a fine needle-like morphology, but with a high crystallinity, likely eliminating the possibility of excessive grain growth that is otherwise expected to occur under high-temperature treatment with long process times. We show that sintering of nanostructured, high crystallinity β-TCP at relatively low temperatures is possible via adjustment of the precursor solution parameters. Such an outcome is important for the use of β-TCP with a fine morphology imitating that of the skeletal tissues, enhancing the osteointegration of a base, load-bearing alloy to the host tissue. MTT analysis was used to test the effect of the obtained β-TCP particles on the viability of MG-63 human osteoblast-like cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles

Bakan

2019

Materials

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“…In the last years there were investigated a lot of chemical and physical characteristics with important effects in functionality in vivo and in vitro: porosity, grain size and roughness [28,49]. These studies demonstrated that BCP are biocompatible, bioactive and osteoconductive [41].…”

Section: Resultsmentioning

confidence: 99%

“…Calcium phosphate-crystals became ideal drug delivery systems, minimizing the effective dose of the drugs and the side effects. A lot of studies presented the outstanding surface interaction properties of ceramics, which make them appropriate candidates for transporting antibiotics, hormones, bone morphogenetic proteins, vitamins, and oncological drugs [28].…”

Section: Resultsmentioning

confidence: 99%

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Management of Collapse Tibial Plateau Fractures Using a Hydroxyapatite-Tricalcium Phosphate Ceramic(ATLANTIK�) and Plate Osteosynthesis

Forna¹,

Scripcaru²,

Onofrei³

et al. 2019

Rev. Chim.

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The treatment of bone defects in complex proximal tibial plateau fractures is a challenging situation and biphasic tricalcium phosphate (BCP) ceramics are considered the most promising alternative to autologous bone graft. The aim of the experimental part was to retrospectively asses the use of Atlantik� BCP (a mixture of 70% Hydroxyapatite and 30% beta-tricalcium phosphate) combined with plate osteosynthesis for management of 27 collapse tibial plateau fractures. All fractures healed after a mean time 2.8 months, while the mean time for disappearance the radiolucent zones between the implanted ceramic and receiving tissue was 15 weeks. We noticed a Neer score of 85 points with no reaction to bone substitute or evidence of biomaterial degradation. The study demonstrated that biphasic ceramic biomaterial Atlantik�, combined with supportive plate osteosynthesis, is an effective synthetic bone substitute due to a fast healing and good quality osseointegration.

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Osteogenic Capability of Vaterite‐Coated Nonwoven Polycaprolactone Scaffolds for In Vivo Bone Tissue Regeneration

Saveleva

Иванов

Chibrikova

et al. 2021

Macromolecular Bioscience

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In current orthopedic practice, bone implants used to-date often exhibit poor osteointegration, impaired osteogenesis, and, eventually, implant failure. Actively pursued strategies for tissue engineering could overcome these shortcomings by developing new hybrid materials with bioinspired structure and enhanced regenerative potential. In this study, the osteogenic and therapeutic potential of bioactive vaterite is investigated as a functional component of a fibrous polymeric scaffold for bone regeneration. Hybrid two-layered polycaprolactone scaffolds coated with vaterite (PCL/CaCO 3 ) are studied during their 28-days implantation period in a rat femur defect. After this period, the study of tissue formation in the defected area is performed by the histological study of femur cross-sections. Immobilization of alkaline phosphatase (ALP) into PCL/CaCO 3 scaffolds accelerates new bone tissue formation and defect repair. PCL/CaCO 3 and PCL/CaCO 3 /ALP scaffolds reveal 37.3% and 62.9% areas, respectively, filled with newly formed bone tissue in cross-sections compared to unmineralized PCL scaffold (17.5%). Bone turnover markers are monitored on the 7th and 28th days after implantation and reveal an increase of osteocalcin level for both PCL/CaCO 3 and PCL/CaCO 3 /ALP compared with PCL indicating the activation of osteogenesis. These findings indicate that vaterite, as an osteoconductive component of polymeric scaffolds, promotes osteogenesis, supports angiogenesis, and facilitates bone defect repair.

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Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Cited by 54 publications

References 44 publications

A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles

A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles

Management of Collapse Tibial Plateau Fractures Using a Hydroxyapatite-Tricalcium Phosphate Ceramic(ATLANTIK�) and Plate Osteosynthesis

Osteogenic Capability of Vaterite‐Coated Nonwoven Polycaprolactone Scaffolds for In Vivo Bone Tissue Regeneration

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