Synthesis of Isomeric Dimers of Deoxycholic Acid Derivatives Linked by 1,2,3-Triazole

Abstract

Melting point values were determined on a Kofler hot-stage apparatus (Boetius). Infrared (IR)

Alkaloids and Isoprenoids Modification by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition (Click Chemistry): Toward New Functions and Molecular Architectures

“…Pore and Ju independently showed the high-yielding preparation of a series of 1,2,3-triazole-tethered bile acid dimers, such as 168 – 171 , involving head-to-tail, head-to-head, and tail-to-tail and other types of linkage (using C-3, C-11, and C-24 positions of cholic and deoxycholic acid). − The deoxycholic acid dimer 169 (R = H) was recently synthesized as a 3,3′,12,12′-tetra- O -acetyl derivative by Paryzek et al Later, Pore expanded his work for the synthesis of other bile acids dimers, trimer 172 , and tetramer 173 (Figure ). These compounds can solubilize the polar cresol red dye in a nonpolar medium and exhibited a reverse micellar behavior in a nonpolar solvent.…”