Synthesis of Isoniazid from Citric Acid

Baizer, Manuel M.; Dub, Michael; Gister, Sidney; Steinberg, N. G.

doi:10.1002/jps.3030450714

Cited by 16 publications

(7 citation statements)

References 8 publications

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“…The acid can be synthesized from boiling citric acid in methanol in presence of ptoluenesulfonic acid. The product so formed is then treated with ammonia solution under pressure resulting in the synthesis of the targeted CZA molecule [30].…”

Section: Resultsmentioning

confidence: 99%

A pH dependent Raman and surface enhanced Raman spectroscopic studies of citrazinic acid aided by theoretical calculations

Sarkar

Chowdhury

Dutta

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Resultsmentioning

confidence: 99%

A pH dependent Raman and surface enhanced Raman spectroscopic studies of citrazinic acid aided by theoretical calculations

Sarkar

Chowdhury

Dutta

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…However, five compounds, 16 (6.96 μM), 19 (6.98 μM), 28 (7.00 μM), 22 (7.86 μM), and 10 (7.90 μM), showed good MIC values that are prominently exhibiting in vitro potency close to isoniazid and higher than ethambutol. Among the other compounds, 13,14,17,18,20,21,24,29,30,31, and 32 are also promising candidates based on their MIC values reported in Table 2 for the inhibitors of Mtb.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Indeed, in these two drugs, heterocyclic moieties play a crucial role in affecting new acquirement. 12 , 13 Moreover, the isonicotinamide moiety-related heterocyclic compound based anti-TB drugs such as isoniazid 14 and ethionamide, 15 have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…First-line drugs such as rifampicin and isoniazid are at present best-practice therapy drugs for the treatment of TB within 6 months. Indeed, in these two drugs, heterocyclic moieties play a crucial role in affecting new acquirement. , Moreover, the isonicotinamide moiety-related heterocyclic compound based anti-TB drugs such as isoniazid and ethionamide, have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of “Chloropicolinate Amides and Urea Derivatives” as Novel Inhibitors for Mycobacterium tuberculosis

et al. 2021

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A series of 30 novel diamino phenyl chloropicolinate fettered carboxamides, urea, and thiourea derivatives were synthesized by coupling of methyl 4-amino-6-(2-aminophenyl)-3-chloropyridine-2-carboxylate with different acid chlorides, urea, and thiourea moieties, respectively. All of these compounds were characterized by 1H and 13C nuclear magnetic resonance spectroscopy, CHN analysis, and high-resolution mass spectra for confirmation of the structures. Two compounds were also characterized by single-crystal X-ray diffraction analysis to confirm the structures obtained by spectral analysis. All these 30 compounds were tested for their in vitro antimycobacterial activity using the microplate alamar blue assay method against Mycobacterium tuberculosis. Five compounds have shown good minimum inhibitory concentration (MIC) values with low cytotoxicity when compared with the reference drugs. Moreover, some of the compounds have high MIC values compared with isoniazid, rifampicin, and so forth and also had shown good reign in the spread of bacteria by the nutrient starvation model. These antimycobacterial activity results have shown a good correlation with molecular docking model analysis with the inhibitors MurB by exhibiting strong interactions. Some of these compounds could be promising candidates against M. tuberculosis for future preclinical agent drug development.

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“…The animals were observed for onset and number of clonic seizures (Baizer et al, 1956) (Table II). ED 50 values for compounds with 95% confi dence limits were calculated for the antagonism of yohimbine-induced clonic seizures according to Austen et al (1961).…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Analgesic and Anticonvulsant Activities of Some Newly Synthesized Trisubstituted Pyridine Derivatives

Salam

Al‐Omar

Khalifa

et al. 2013

Zeitschrift Für Naturforschung C

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A series of novel pyridine carbohydrazide derivatives were synthesized from the reaction of 2-chloro-6-hydrazino-isonicotinic acid hydrazide with selected active reagents. All prepared compounds were tested as analgesic and anticonvulsant agents. The pharmacological screening showed that many of these compounds have good activities comparable to those of valdecoxib and carbamazepine as reference drugs.

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Synthesis of Isoniazid from Citric Acid

Cited by 16 publications

References 8 publications

A pH dependent Raman and surface enhanced Raman spectroscopic studies of citrazinic acid aided by theoretical calculations

A pH dependent Raman and surface enhanced Raman spectroscopic studies of citrazinic acid aided by theoretical calculations

Design and Synthesis of “Chloropicolinate Amides and Urea Derivatives” as Novel Inhibitors for Mycobacterium tuberculosis

Analgesic and Anticonvulsant Activities of Some Newly Synthesized Trisubstituted Pyridine Derivatives

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