Synthesis of Macrocycles and Click Chemistry

Copper(i)-catalyzed click chemistry in deep eutectic solvent for the syntheses of β-d-glucopyranosyltriazoles

“…In the past two decades, various copper( i ) complexes have been extensively used as catalysts in CuAAC reactions. 29–45 The active copper( i ) species required for this chemical transformation can also be generated in situ by the reaction of copper( ii ) salt with a reducing agent such as sodium ascorbate. However, problem arises with the stability of the copper( i ) complexes during the course of reaction and poor solubility of copper-( i ) salts in common organic solvents.…”

“…The impact of click chemistry has already been spread out in diverse fields of science. 29–45 Along with the successful development of CuAAC reactions in various fields of chemistry, its application in carbohydrate chemistry has been parallelly explored. 46–58 In this regard, Tiwari and co-workers elegantly illustrated the application of click chemistry in glycoscience.…”

Growing Impact of Intramolecular Click Chemistry in Organic Synthesis

“…Although over 175 reviews have been addressed with a broad theme on 'click chemistry', [6] however comprehensive and critical report on intramolecular azide-alkyne cycloaddition reaction is still little reviewed in the literature. [54,55] Considering the above mentiond facts, there is a need of comprehensive overview focused on recent progress on regioselective click reactions of diverse azido-alkyne precursors performed in intramolecular fashions. Thus, we wish to report herein the recent approaches on intramolecular azide-alkyne Click Chemistry with their emerging applications in various disciplines of science and technology.…”