Coordination
of 1,4-disubstituted 1,2,3-triazoles L
1
and L
2
with [(p-cymene)RuCl2]2 followed
by dehydrochlorination in the presence of a base resulted in the formation
of complexes 1 and 2, respectively. Both
were tested for the transfer hydrogenation of aldehydes and ketones
in air using ecologically benign and cheap ethanol as the hydrogen
source in the presence of a catalytic amount of a base. Air-stable
complex 1 was proved to be an active catalyst for the
transfer hydrogenation of a wide variety of aromatic and aliphatic
aldehydes and ketones bearing various functionalities. Catalyst 1 was also effective for the transfer hydrogenation of carbonyls
using the simplest primary alcohol, methanol, under aerobic conditions.
Under the present catalytic protocol, labile or reducible functionalities
such as nitro, cyano, and ester groups were tolerated. Good selectivity
was also observed for acyclic α,β-unsaturated carbonyls.
However, this catalytic protocol was not selective for 2-cyclohexen-1-one
as both alkene and keto moieties were reduced. The transfer hydrogenations
are believed to proceed via a ruthenium-hydride intermediate. Finally,
transfer hydrogenation of acetophenone using isopropanol as a commonly
used hydrogen source was also performed and the sustainable and green
credentials of these catalytic protocols utilizing methanol, ethanol,
and isopropanol were compared with the help of the CHEM21 green metrics
toolkit.
Selective and efficient hydrosilylations of esters to alcohols by a well-defined manganese(I) complex with a commercially available bisphosphine ligand are described. These reactions are easy alternatives for stoichiometric hydride reduction or hydrogenation, and employing cheap, abundant, and nonprecious metal is attractive. The hydrosilylations were performed at 100 °C under solvent-free conditions with low catalyst loading. A large variety of aromatic, aliphatic, and cyclic esters bearing different functional groups were selectively converted into the corresponding alcohols in good yields.
Herein we report efficient catalytic hydrosilylations of nitroarenes to form the corresponding aromatic amines using a well-defined manganese(II)−NNO pincer complex with a low catalyst loading (1 mol %) under solvent-free conditions. This base-metal-catalyzed hydrosilylation is an easy and sustainable alternative to classical hydrogenation. A large variety of nitroarenes bearing various functionalities were selectively transformed into the corresponding aromatic amines in good yields. The potential utility of the present catalytic protocol was demonstrated by the preparation of commercial drug molecules.
A well-defined and readily available
air-stable dimeric iridium(III)
complex catalyzed α-alkylation of arylacetonitriles using secondary
alcohols with the liberation of water as the only byproduct is reported.
The α-alkylations were efficiently performed at 120 °C
under solvent-free conditions with very low (0.1–0.01 mol %)
catalyst loading. Various secondary alcohols including cyclic and
acyclic alcohols and a wide variety of arylacetonitriles bearing different
functional groups were converted into the corresponding α-alkylated
products in good yields. Mechanistic study revealed that the reaction
proceeds via alcohol activation by metal–ligand cooperation
with the formation of reactive iridium-hydride species.
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