Synthesis of magnesium nanoparticle for NIR-II-photoacoustic-imaging-guided synergistic burst-like and H2 cancer therapy

Liu, Luntao; Wu, Ying; Ye, Jiamin; Fu, Qinrui; Su, Lichao; Wu, Zongsheng; Feng, Ji; Chen, Zhongxiang; Song, Jibin

doi:10.1016/j.chempr.2022.07.001

Cited by 29 publications

(21 citation statements)

References 38 publications

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“…The maximum absorption peak of AuNNP@PAA/NIC NPs was found to be around 527 nm. However, NTR-treated AuNNP@PAA/NIC NPs showed an extraordinary red-shift in their absorption wavelength at 970 nm due to the aggregation of gold NPs, which was attributed to the plasmon coupling effects of nanogapped gold nanospheres (Figure d). ,, We also tested the PA curves of AuNNP@PAA/NIC NPs before and after the incubation of NTR. The result revealed that NTR-responsive AuNNP@PAA/NIC NPs showed a significantly enhanced NIR-II PA signal (Figure e).…”

Section: Resultsmentioning

confidence: 99%

“…In deep scattering environments, photoacoustic (PA) imaging is a promising imaging technique that may give high optical contrast and high ultrasonic spatial resolution, overcoming the drawbacks of pure optical and ultrasonic imaging. − The capacity to do label-free imaging at all scales is another significant benefit of PA imaging over other imaging modalities . Recent advances in biological applications have drawn great interest in PA imaging in the second near-infrared window (NIR-II, 1000–1700 nm), which offers deeper penetration depth, better resolution, and less background noise than PA imaging in the first near-infrared window (NIR-I, 700–1000 nm). − NIR-II PA imaging has been used for various purposes, including, but not limited to, monitoring the distribution of materials in the body, visually monitoring bioactive molecules, and imaging-guided therapy. − …”

Section: Introductionmentioning

confidence: 99%

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Hypoxia-Responsive Aggregation of Gold Nanoparticles for Near-Infrared-II Photoacoustic Imaging-Guided Enhanced Radiotherapy

et al. 2023

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By directly harming cancer cells, radiotherapy (RT) is a crucial therapeutic approach for the treatment of cancers. However, the efficacy of RT is reduced by the limited accumulation and short retention time of the radiosensitizer in the tumor. Herein, we developed hypoxia-triggered in situ aggregation of nanogapped gold nanospheres (AuNNP@PAA/NIC NPs) within the tumor, resulting in second nearinfrared window (NIR-II) photoacoustic (PA) imaging and enhanced radiosensitization. AuNNP@PAA/NIC NPs demonstrated increased accumulation and retention in hypoxic tumors, mainly due to the hypoxia-triggered aggregation. After aggregation of AuNNP@PAA/ NIC NPs, the absorption of the system extended from visible light to NIR-II light owing to the plasmon coupling effects between adjacent nanoparticles. Compared to the normoxic tumor, the PA intensity at 1200 nm in the hypoxic tumor increased from 0.42 to 1.88 at 24 h postintravenous injection of AuNNP@PAA/NIC NPs, leading to an increase of 4.5 times. This indicated that the hypoxic microenvironment in the tumor successfully triggered the in situ aggregation of AuNNP@PAA/NIC NPs. The in vivo radiotherapeutic effect demonstrated that this hypoxia-triggered in situ aggregation of radiosensitizers significantly enhanced radiosensitization and thus resulted in superior cancer radiotherapeutic outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypoxia-Responsive Aggregation of Gold Nanoparticles for Near-Infrared-II Photoacoustic Imaging-Guided Enhanced Radiotherapy

et al. 2023

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“…For example, Liu et al synthesized Mg nanoflowers (MgNFs) with broad absorption over the entire NIR-II window and good performance in NIR-II PAI, and then coated MgNFs with pH-responsive polymer (polyethylene glycol-b(poly(methyl methacrylate)-co-poly(4-vinylpyridine) (PEG-b-PMMVP)), achieving the generated H 2 precisely localized in an acid tumor environment and bubbles-enhanced ultrasound signals of tumor sites. [179]…”

Section: Other Pai Probesmentioning

confidence: 99%

“…[223][224][225][226] H 2 therapy is a safe and nondrug strategy in tumor therapy, not only because H 2 bubble-enhanced PAI and USI can be used for navigating cancer surgery, but the bubbles cause mechanical destruction of lysosomes and induct generation of ROS, leading to DNA damage and cell apoptosis. [179] In the future, H 2 therapy could combine with PTT or PTT-based combined brain tumor therapy, which would be beneficial for further improving therapeutic efficacy.…”

Section: Photothermal Therapymentioning

confidence: 99%

Second Near‐Infrared (NIR‐II) Window for Imaging‐Navigated Modulation of Brain Structure and Function

Zhang

Chen

Wang

et al. 2023

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For a long time, optical imaging of the deep brain with high resolution has been a challenge. Recently, with the advance in second near‐infrared (NIR‐II) bioimaging techniques and imaging contrast agents, NIR‐II window bioimaging has attracted great attention to monitoring deeper biological or pathophysiological processes with high signal‐to‐noise ratio (SNR) and spatiotemporal resolution. Assisted with NIR‐II bioimaging, the modulation of structure and function of brain is promising to be noninvasive and more precise. Herein, in this review, first the advantage of NIR‐II light in brain imaging from the interaction between NIR‐II and tissue is elaborated. Then, several specific NIR‐II bioimaging technologies are introduced, including NIR‐II fluorescence imaging, multiphoton fluorescence imaging, and photoacoustic imaging. Furthermore, the corresponding contrast agents are summarized. Next, the application of various NIR‐II bioimaging technologies in visualizing the characteristics of cerebrovascular network and monitoring the changes of the pathology signals will be presented. After that, the modulation of brain structure and function based on NIR‐II bioimaging will be discussed, including treatment of glioblastoma, guidance of cell transplantation, and neuromodulation. In the end, future perspectives that would help improve the clinical translation of NIR‐II light are proposed.

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“…Magnesium (Mg) metal, as a strong reductive metal, could react with H 2 O and spontaneously generate H 2 gas. Mg and its alloys have been widely used as biodegradable implants for tissue repair/regeneration in clinics, but only until recently have researchers utilized their H 2 generation capability for disease treatments [ 26 ]. For example, poly (lactic- co -glycolic acid) (PLGA) microparticles containing Mg powder were intra-muscularly close to the osteoarthritis knee to tackle inflammation through H 2 therapy [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

Wang

Yang

et al. 2023

Bioactive Materials

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Synthesis of magnesium nanoparticle for NIR-II-photoacoustic-imaging-guided synergistic burst-like and H2 cancer therapy

Cited by 29 publications

References 38 publications

Hypoxia-Responsive Aggregation of Gold Nanoparticles for Near-Infrared-II Photoacoustic Imaging-Guided Enhanced Radiotherapy

Hypoxia-Responsive Aggregation of Gold Nanoparticles for Near-Infrared-II Photoacoustic Imaging-Guided Enhanced Radiotherapy

Second Near‐Infrared (NIR‐II) Window for Imaging‐Navigated Modulation of Brain Structure and Function

Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

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