Synthesis of metal‐free poly(p‐dioxanone) by phosphazene base catalyzed ring‐opening polymerization

Abstract

Poly(p-dioxanone) (PPDO) has received significant attention due to its good biocompatibility and fast biodegradation profiles. In addition, PPDO is a polymer with high potential in biomedical applications. However, the conventional syntheses of PPDO via the ring-opening polymerization (ROP) of p-dioxanone (PDO) often use a metallic catalyst, which significantly limits its biorelated applications. This investigation was focused on the synthesis of metal-free PPDO by using phosphazene base t-BuP 4 as the catalyst. The effects of the reaction conditions including temperature, reaction time, initiators, and feed molar ratios were studied in detail by nuclear magnetic resonance spectroscopy, viscosimetry, differential scanning calorimetry, and thermogravimetric analysis. The results showed that t-BuP 4 exhibited especially high activity in catalyzing alcohol or aniline to initiate the ROP of PDO, consequently resulting in metal-free PPDOs. The polymerization was optimum at a reaction temperature of approximately 1008C and 88.7% of PDO was consumed. The viscosity-average molecular weights of the resulting polymer reached as high as 2.09 3 10 4 g/mol. The molar ratios of [PDO]/[t-BuP 4 ] also had an obvious effect on both the polymerization and the resulting polymer. Increasing [PDO]/[t-BuP 4 ] ratios facilitated the molecular weight growth, whereas the conversions of PDO significantly decreased. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43030.

Organic Catalysis for Ring-Opening Graft Polymerization of p-Dioxanone with Xylan in Ionic liquid

“…In addition, organic catalysts are suitable for a range of reaction conditions, solvents, and monomers, and are typically easy to remove from the resultant polymers [ 39 ]. Generally, in the presence of alcohol initiators, the organocatalytic systems, like pyridines [ 41 ], phosphines [ 42 , 43 ], N-heterocyclic carbenes (NHC) [ 44 ], guanidines [ 2 ], and amidines [ 45 ] can generate linear polyesters. Of the most widely used organic catalysts are the strong bases of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).…”

The Journey of Alternative and Sustainable Substitutes for “Single‐Use” Plastics

“…It is produced by the ring opening polymerization reaction of p ‐dioxanone in the presence of catalysts like zirconium acetylacetone, zinc L‐lactate, phosphazene base t‐BuP4, stannous octoate, etc. [ 63 ] Its glass transition temperature is −10 to 0 °C. The thermal stability of PPDO can be increased by increasing the molecular mass.…”