Synthesis of Metal-Organic Framework from Iron Nitrate and 2,6-Naphthalenedicarboxylic Acid and Its Application as Drug Carrier

Abstract

Metal-organic frameworks (MOFs) are highly crystalline porous organic-inorganic materials that are comprised of metal salts and organic linkers. The common synthetic methodologies of MOFs include: solvothermal, microwave-assisted, electrochemical, mechanochemical, and sonochemical routes. The synthesized MOF particles can be characterized using several characterization techniques including: X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and other analytical techniques. Recently, MOFs have garnered increasing attention due to their potential applications in numerous areas including: catalysis, gas storage and separation, drug delivery, and others. In this research paper, a new metal-organic framework was synthesized successfully from iron nitrate and 2,6-naphthalenedicarboxylic acid (1) by means of microwave irradiation (Fe-NDC-M) and (2) solvothermally using a conventional electric oven (Fe-NDC-O). They were characterized using XRD, SEM, FTIR, energy-dispersive X-ray (EDS), thermogravimetric analysis (TGA), and N2 sorption experiments. The characterization results showed that the synthesized samples were crystals with a rod-like shape. The particle diameters ranged between 50-80 nm with a length of 300-450 nm. The BJH adsorption averagepore diameters were found to be 148.551 Å and 139.265 Å for Fe-NDC-M and Fe-NDC-O, respectively. As a result, the new Fe-NDC-MOF particles can be used as nanocarriers for anticancer drug delivery applications utilizing the enhanced permeability and retention effect.

Millimeter-Sized Metal-Organic Framework Single Crystals without Inversion Symmetry: Controlled Growth and Self-Assembly Mechanism

“…Metal-organic frameworks (MOFs) are an established class of porous materials with demonstrated use in a wide range of applications that benefit from their record-high surface areas, including gas storage, 1 gas separation, 1,2 water purification, 3 fuel cells, 4 drug delivery, 5,6 catalysis, 7 and chemical sensing. 8,9 MOFs are also considered promising materials for applications in nonlinear optics, [10][11][12][13][14] given the variety of non-centrosymmetric structures with large optical nonlinearities that can be formed, 12,15 in comparison with the limited number of inorganic standards available in industry.…”

Millimeter-Scale Zn(3-ptz)2 Metal–Organic Framework Single Crystals: Self-Assembly Mechanism and Growth Kinetics

“…Metal–organic frameworks (MOFs) are an established class of porous materials with demonstrated use in a wide range of applications that benefit from their record-high surface areas, including gas storage, gas separation, , water purification, fuel cells, drug delivery, , catalysis, and chemical sensing. , MOFs are also considered as promising materials for applications in nonlinear optics, − given the variety of noncentrosymmetric structures with large optical nonlinearities that can be formed, , in comparison with the limited number of inorganic standards available in the industry.…”

Synthesis of a Ce-Based MOF-76 with High Yield: A Study of Reaction Parameters Based on a Factorial Design

“…[2][3][4] MOFs are open networks that exhibit crystalline structures, different pore sizes (micro and mesoporous), open metallic sites, active functional groups, low density and large surface area. [4][5][6] Due to this diversity of structures, MOFs have been applied in different areas, such as catalytic reactions, 1 gas storage, 3 luminescent sensors, 7 drug delivery, 8,9 ion exchange, 10 and component separation. 11 MOF-76 represents a family of compounds formed by lanthanide ions and BTC as linker, which was firstly synthesized by Rosi et al 12 and since then it had been synthesized and studied for different applications.…”