Synthesis of Methyl Hexaacetyl-Tunicaminyl Uracil

Abstract

A C11-carbohydrate named tunicamine, which is a component of antibiotic tunicamycins, has been synthesized in a form of polyacetyl derivative. From the tunicamine derivative, a nucleoside moiety of the antibiotic designated as tunicaminyl uracil has been successfully synthesized.

Nitroaldol-reaction of aldehydes in the presence of non-activated Mg:Al 2:1 hydrotalcite; a possible new mechanism for the formation of 2-aryl-1,3-dinitropropanes

“…They are particularly versatile intermediates for the synthesis of nitroalkenes, 2-aminoalcohols and 2-nitro-ketones. They are also useful intermediates in the synthesis of valuable pharmaceuticals and pharmaceutical intermediates such as (S)-propanolol, 2 or (S)-(K)-pindolol, 3 antibiotics (e.g., ezomycin, 4 tunicamycin 5 ), natural products such as the sex pheromone of the Douglas Fir Tussock moth 6 or cyclopeptide alkaloids. 7 Moreover, 2-nitroalkanol derivatives are important as fungicides.…”

Biocatalytic Approaches to the Henry (Nitroaldol) Reaction

“…[9][10][11][12][13][14] Furthermore, β-amino alcohols are constituents of many active pharmaceutical ingredients [15][16][17][18][19] , e.g. The preparation of these target compounds in optically pure form has been the focus of much research and there has been an emergence of biocatalytic protocols in the past decade.…”

A new sustainable protocol for the synthesis of nitroaldol derivatives via Henry reaction under solvent-free conditions

“…The reaction products, namely nitroaldol compounds, are versatile intermediates to get access to nitroalkanes, 2-aminoalcohols and 2-nitroketones (1, 2). Furthermore, many biologically and pharmacologically active compounds are synthesised via such intermediates (3)(4)(5)(6)(7)(8) .…”