This contribution reports the preparation and use of a new immobilized catalyst, PS-DABCOF (9), which has been specifically designed to access for the first time the efficient β-azidation of α,β-unsaturated carboxylic acids.

aration of two representative N-Boc-b-amino ketones starting from the corresponding enones with E-factors of 3.2 and 2.7, respectively. Scheme 3. Preparation of b-azido ketones 7a, 7f and 7h using a cyclic continuous-flow reactor.Scheme 4. Preparation of N-Boc-b-amino ketones 9.

An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting α-hydroxyphosphonates were isolated with simple workup procedures. A large scale protocol for the preparation of a representative α-hydroxyphosphonate 3a has been also set up using a flow reactor.

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