Synthesis of mixed phosphorotrithioates via thiol coupling with bis(diisopropylamino)chlorophosphine and sulphenyl chloride

Abstract

In this study, we report a novel and efficient one-pot synthesis of mixed phosphorotrithioates under mild conditions at ambient temperature, obviating the requirement for supplementary additives.

Synthesis of unsymmetric phosphorotrithioates by sequential coupling of 1,1-dichloro-N,N-diethylphosphanamine with thiols and sulfenyl chloride

“…Based on the comprehensive results derived from our control experiments and the valuable insights gained from prior studies, 13,14 we propose a plausible mechanism to elucidate the intricate pathway of the current reaction, as depicted in Fig. 2B.…”