Synthesis of molecular imprinted polymer nanoparticles followed by application of response surface methodology for optimization of metribuzin extraction from urine samples

Heravizadeh, Omid Reza; Khadem, Monireh; Nabizadeh, Ramin; Shahtaheri, Seyed Jamaled­din

doi:10.1007/s11696-018-0546-z

Cited by 15 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2) accommodation of several parameters, for example, process, variety and separate parameters; (3) optimization of designs can be done when the design-space is constrained. 2,32 There are several types of design for experiments, such as one-factor-at-a-time and the response surface methodology (RSM) design. Taking into account the disadvantages of conventional one-factor-at-a-time optimization method such as requiring more runs for the same precision, time-consuming, high overall costs, failure to estimate interactions and missing optimal settings of parameters, using statistical methods such as response surface methodology (RSM) can be performed to enhance the production of a particular substance by optimization of operational variables.…”

Section: Introductionmentioning

confidence: 99%

Toluene adsorption on porous Cu–BDC@OAC composite at various operating conditions: optimization by response surface methodology

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Toluene adsorption on porous Cu–BDC@OAC composite at various operating conditions: optimization by response surface methodology

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Because the adsorption capacity of MIPs was usually within a range of concentrations, , the concentrations of the mixture needed to be considered. According to the results of the static adsorption, 0.0125 mM was applied as the low concentration, and 0.05 mM (which was nearly the saturation concentration of absorption) was used as the high concentration condition.…”

Section: Resultsmentioning

confidence: 99%

A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

et al. 2019

View full text Add to dashboard Cite

Molecular imprinted polymers (MIPs) have been widely applied in the separation of compounds in complex matrixes due to the high selectivity for molecular recognition. However, MIPs not only adsorb the targeted molecule but also adsorb structurally similar analogues, which leads to some loss of selectivity. In this work, for improvement of selectivity of MIPs, a novel solid-phase extraction method with two MIPs in two steps (TMIPs-TSPE) was established. As a demonstration, two MIPs were prepared by using quercetin as the template and 4-vinylypyridine (4VP) and acrylamide (AM) as representative functional monomers, respectively. The adsorption properties and kinetic characteristics of the two MIPs showed that they had a distinct adsorption capacity and adsorption mechanism, which is the basis for establishment of TMIPs-TSPE. The TMIPs-TSPE method first used one of the two MIPs as adsorbent to extract molecules from a solution mixture containing quercetin and three analogues. Then the other MIP was used to achieve a second extraction of the extracted molecules from the first step. The results showed that the unique targeted molecule quercetin was extracted, which illustrates that TMIPs-TSPE improved the specificity of the MIPs. The process of molecular recognition can be influenced by the intensity of binding sites between MIPs and molecules. Moreover, it may also depend on the spatial orientation of molecules entering the cavities of MIPs, which deserves more attention as one important property for the development of molecular imprinting. These results demonstrated that the novel TMIPs-TSPE method contributes to the improved selectivity of MIPs.

show abstract

“…Often, the determination of the best formulation ratio of certain templates for MIP requires a trial‐and‐error approach, which is a lengthy process. In traditional optimization methods such as one variable at a time, the process is time‐consuming, and the interaction that involves more than two response factors is not fully extrapolated 17 . Therefore, substantial developments were conducted to optimize both the imprinting process and the optimum formulation of MIP, aiming to increase the binding capacity and indirectly expanding its application in DDS.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐assisted molecularly imprinted polymer synthesis for chemometric and rebinding mechanism of drug release applications

Lawai,

Ngaini,

Farooq

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

Synthesis of molecularly imprinted polymers (MIP) has gained wide interest as drug delivery vehicles in recent years. The conventional one‐variable‐at‐a‐time method for determining the best formulation ratio of MIP templates is resource‐ and time‐consuming. Thus, this study focused on the response surface methodology optimization of the best formulation for MIP preparation using methacrylic acid and divinylbenzene as functional monomer and cross‐linker, respectively. Two preparation systems were studied, namely microwave (MW)‐assisted and conventional synthesis. The MIPs showed spherical particles with smaller particle sizes (500 nm–1.45 μm) and higher yields (0.5–1.2 g) via MW‐assisted synthesis as compared to the conventional synthesis (size 660 nm–3.65 μm, yield 0.5–1.15 g). MW‐assisted synthesis is faster and more efficient to synthesize controlled shapes and sizes of MIP particles. The rebinding properties of prepared MIP via MW were higher (7.15 ± 0.02 mg/g) than conventional synthesis (3.00 ± 0.31 mg/g). The empirical models were developed to correlate the output response of rebinding properties and input variables. The analysis of variance confirmed that experimental data were superbly fitted to the proposed response models. A satisfactory correlation between the experimental and predicted values was obtained by both MIP prepared via MW‐assisted and conventional synthesis.

show abstract

Synthesis of molecular imprinted polymer nanoparticles followed by application of response surface methodology for optimization of metribuzin extraction from urine samples

Cited by 15 publications

References 51 publications

Toluene adsorption on porous Cu–BDC@OAC composite at various operating conditions: optimization by response surface methodology

Toluene adsorption on porous Cu–BDC@OAC composite at various operating conditions: optimization by response surface methodology

A SPE Method with Two MIPs in Two Steps for Improving the Selectivity of MIPs

Microwave‐assisted molecularly imprinted polymer synthesis for chemometric and rebinding mechanism of drug release applications

Contact Info

Product

Resources

About