Synthesis of monodispersed molecularly imprinted polymer particles for high-performance liquid chromatographic separation of cholesterol using templating polymerization in porous silica gel bound with cholesterol molecules on its surface

Kitahara, Keiichi; Yoshihama, Isao; Hanada, Takako; Kokuba, Hiroko; Arai, Sadao

doi:10.1016/j.chroma.2010.09.041

Cited by 53 publications

(27 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recognition ability of the MIP column was evaluated using cholesterol, cholesterol esters and fatty acid methyl esters by comparison with the NIP column, which showed a high affinity with K MIP 0 /K NIP 0 imprinting factors of 45.7. 493 To obtain small sized molecularly imprinted microspheres, Lai et al synthesized MIPs (3-5 mm) by precipitation polymerization and used them as HPLC and SPE packing materials for the analysis of an anti-AIDS drug emtricitabine (FTC). Chromatographic evaluation and characterization illustrated that the MIP column exhibited good recognition and affinity to FTC with the imprinting factor of 2.26.…”

Section: Synthesized (à)-Ephedrine-mips By Bulk Polymerization and Usmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

View full text Add to dashboard Cite

a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

show abstract

Section: Synthesized (à)-Ephedrine-mips By Bulk Polymerization and Usmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A hydrophilic molecularly imprinted polymer has been prepared using acryloyl-containing hydrophilic monomers and derivatives of cyclodextrin in the presence of cholesteryl acrylate as template [19]. Cross-linked poly(methacrylic acid-co-ethylene glycol dimethacrylate) and cholesterol-imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-tyrosine methylester) particles synthesized by means of bulk method [20,21] and polymerization with template-immobilized silica gel [22] are also examples of imprinted materials for cholesterol extraction. To the best of our knowledge, there are no reports available in the literature on molecularly imprinted hybrid polymers for cholesterol extraction and still few attempts have been made for the preparation of molecularly imprinted polymers selective to the other analytes.…”

Section: Introductionmentioning

confidence: 99%

Improved selective cholesterol adsorption by molecularly imprinted poly(methacrylic acid)/silica (PMAA–SiO2) hybrid material synthesized with different molar ratios

Clausen

Pires

Tarley

2014

Materials Science and Engineering: C

View full text Add to dashboard Cite

“…1 MIPs have some advantages, excluding stability, ease of preparation, low cost, and reusability; which make it to have a wide variety of applications, including in chromatography, 2,3 solid phase extraction, [4][5][6][7] chemical sensors, 8 artificial antibodies, 9 and drug delivery, 10,11 where the MIPs act as a recognition element. MIPs are three-dimensional network polymers prepared in the presence of template molecule.…”

mentioning

confidence: 99%

Synthesis and Recognition of Nano Pore Molecularly Imprinted Polymers of Thymol on the Surface of Modified Silica Nanoparticles

Masoumi

Jahanshahi

2015

Adv Polym Technol

View full text Add to dashboard Cite

ABSTRACT:To the best of our knowledge, for the first time in this study, nano pore molecularly imprinted polymers were prepared using thymol as a template. A molecularly imprinting polymer with high performance for recognizing thymol was prepared by a novel surface molecular imprinting technique. First, silica nanoparticles were modified with γ -methacyloxypropyl trimethoxysilane (KH-570) as a support material. Afterward, surface molecularly imprinted polymers (SMIP) were obtained through polymerization with methacrylic acid as the functional monomer and trimethylolpropane trimethacrylate as the cross-linking agent. The produced polymers were characterized by transmission electron microscopy, scanning electron microscopy, Brunauer-Emmett-Teller analysis as well as Fourier transform infrared spectroscopy. The SMIP were obtained with the average core shell thickness of 17 nm, an average pore diameter of 3.9 nm, and the high specific surface area of 282.3 m 2 g −1 . The adsorption properties were revealed by batch binding experiments. The results indicated that the SMIP had higher binding capacity for thymol than its nonimprinted polymers. The selectivity of the SMIP obtained was clarified by using thymol and structurally related compounds. The selectivity coefficient of SMIP for thymol with respect to competition species obtained was 2.44, which revealed SMIP had good selectivity and site accessibility for thymol. A kinetic binding study showed that adsorption capacity of SMIP increased continuously with time and reached saturation adsorption at 90 min. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2016, , 21548; View this article online at wileyonlinelibrary.com.

show abstract

Synthesis of monodispersed molecularly imprinted polymer particles for high-performance liquid chromatographic separation of cholesterol using templating polymerization in porous silica gel bound with cholesterol molecules on its surface

Cited by 53 publications

References 19 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Improved selective cholesterol adsorption by molecularly imprinted poly(methacrylic acid)/silica (PMAA–SiO2) hybrid material synthesized with different molar ratios

Synthesis and Recognition of Nano Pore Molecularly Imprinted Polymers of Thymol on the Surface of Modified Silica Nanoparticles

Contact Info

Product

Resources

About