Synthesis of multifunctional miktoarm star polymers <i>via</i> an RGD peptide-based RAFT agent

Chen, Chao; Guo, Xiaofeng; Du, Jinhong; Choi, Bonnie; Tang, Houliang; Feng, Anchao; Thang, San H.

doi:10.1039/c8py01355a

Cited by 21 publications

(23 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of monomers can be easily polymerized with controllable molecular weights (MWs) and low polydispersity (PDI) [15,16,17,18,19,20,21]. Among LPs, reversible-deactivation radical polymerizations (RDRPs) are one of widely used methods, mainly covering atom transfer radical polymerization (ATRP) [22,23,24,25] and derivatives [26,27,28,29], reversible addition–fragmentation chain transfer (RAFT) polymerization [30,31,32], nitroxide-mediated radical polymerization (NMP) [33], ring-opening (metathesis) polymerization (RO(M)P) [34,35], and unique chain-growth condensation polymerization (CGCP) [15,19,36]. Furthermore, several recent modelling studies demonstrated the emergence of joint collaboration between chemists and engineers in the field of LP.…”

Section: Introductionmentioning

confidence: 99%

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Tsai

Chang

et al. 2019

Polymers

View full text Add to dashboard Cite

An effective method of oxidation from paper pulps via 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) compound to obtain TEMPO-oxidized cellulose nanofibers (TOCNs) was demonstrated. Following by acylation, TOCN having an atom transfer radical polymerization (ATRP) initiating site of bromoisobutyryl moiety (i.e., TOCN–Br) was successfully obtained. Through a facile and practical technique of surface-initiated initiators for continuous activator regeneration atom transfer radical polymerization (SI ICAR ATRP) of methyl methacrylate (MMA) from TOCN–Br, controllable grafting polymer chain lengths (Mn = ca. 10k–30k g/mol) with low polydispersity (PDI < 1.2) can be achieved to afford TOCN–g–Poly(methyl methacrylate) (PMMA) nanomaterials. These modifications were monitored by Fourier-transform infrared spectroscopy (FT–IR), scanning electron microscopy (SEM), electron spectroscopy for chemical analysis (ESCA), and water contact angle analysis. Eventually, TOCN–g–PMMA/PMMA composites were prepared using the solvent blending method. Compared to the pristine PMMA (Tg = 100 °C; tensile strength (σT) = 17.1 MPa), the composites possessed high transparency with enhanced thermal properties and high tensile strength (Tg = 110 °C and σT = 37.2 MPa in 1 wt% TOCN containing case) that were investigated by ultraviolet-visible spectroscopy (UV-Vis), thermogravimetric analysis (TGA), dynamic mechanical analysis (DMA), and tensile tests. We demonstrated that minor amounts of TOCN–g–PMMA nanofillers can provide high efficacy in improving the mechanical and thermal properties of PMMA matrix.

show abstract

Section: Introductionmentioning

confidence: 99%

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Tsai

Chang

et al. 2019

Polymers

View full text Add to dashboard Cite

show abstract

“…The difference in responsive behavior (pH 7 to pH 10) can be ascribed to the specific interactions between the carboxylic acid group and Ca 2+ . 35 According to our hypothesis (Scheme 2), another possible reason is that as the end-groups were gradually ionized, the electrostatic repulsion increased leaded to the enlarging chain spacing with a decrease in the rigid region and an increase in the amount of flexible chains (Scheme 2b), finally caused an increase in UCST. In other words, carboxylic end-groups could also affect UCST by changing the chain conformation.…”

Section: -38mentioning

confidence: 85%

Synthesis of star-shaped polyzwitterions with adjustable UCST and fast responsiveness by a facile RAFT polymerization

Sun

et al. 2020

Polym. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Peptide-functionalized macroinitiators have been designed to prepare linear and star polymers bearing a peptide at the extremity of the polymer chain. [232] Different approaches and polymerization techniques have been explored including NMP, [233] ATRP, [234] and RAFT polymerization [235] from a peptide grafted on the resin, peptide-bearing initiator or chain transfer agent used under ATRP [236] and RAFT [237][238][239] polymerization conditions, ring-opening polymerization of N-carboxyanhydrides from peptide-PEG macroinitiator. [240] The use of peptide-containing macromonomers afford polymers bearing peptides on the side chains of the polymer backbone.…”

Section: Peptide Conjugation On Hbpsmentioning

confidence: 99%

Synthesis and functionalization of hyperbranched polymers for targeted drug delivery

Kavand

Anton

Vandamme

et al. 2020

Journal of Controlled Release

108

View full text Add to dashboard Cite

Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as optical, electronic and magnetic materials, coatings, additives, supramolecular chemistry, and biomedicine. HBPs have gained attention for the development of drug delivery systems due to the presence of internal cavities in their three-dimensional globular structure that can be used to encapsulate drugs and their facile synthesis as compared to dendrimers. The composition, topology, and functionality of HBPs have been tuned to design drug carriers with better efficacies. Recent advances have been reported to introduce functional groups to enhance targeting tumor cells. HBPs have been modified to promote passive and active targeting. This review article will describe the different routes to synthesize hyperbranched polymer, their use as drug carriers for targeted drug delivery, and their functionalization with ligands for active targeting through various synthesis strategies to give the reader an extended overview of the progresses accomplished in this field. The modification of HBPs with ligands such as peptides, oligonucleotides, and folic acid have been demonstrated to enhance the accumulation of the drug selectively at the tumor sites. The potential uses and developments of HBPs as nanoobjects for theranostics for example are discussed as perspectives.

show abstract

Synthesis of multifunctional miktoarm star polymers via an RGD peptide-based RAFT agent

Abstract: A “grafting from” approach for facile access of multifunctional miktoarm star polymers containing peptide arms.

Cited by 21 publications

References 43 publications

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Surface-Initiated Initiators for Continuous Activator Regeneration (SI ICAR) ATRP of MMA from 2,2,6,6–tetramethylpiperidine–1–oxy (TEMPO) Oxidized Cellulose Nanofibers for the Preparations of PMMA Nanocomposites

Synthesis of star-shaped polyzwitterions with adjustable UCST and fast responsiveness by a facile RAFT polymerization

Synthesis and functionalization of hyperbranched polymers for targeted drug delivery

Contact Info

Product

Resources

About