Synthesis of Multiplexed Biofluidic Microchips

Pfeiffer, Anton; Mukherjee, Tamal; Hauan, Steinar

doi:10.1007/1-4020-5123-9_11

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…A channel routing problem for continuous-flow microfluidic biochips has been investigated in [42]. This routing problem is similar to the classical single-layer VLSI routing problem.…”

Section: Droplet Routing Methodsmentioning

confidence: 99%

Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Chakrabarty¹

2006

International Conference on Design and Test of Integrated Systems in Nanoscale Technology, 2006. DTIS 2006.

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“…A channel routing problem for continuous-flow microfluidic biochips has been investigated in [42]. This routing problem is similar to the classical single-layer VLSI routing problem.…”

Section: Droplet Routing Methodsmentioning

confidence: 99%

Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Chakrabarty¹

2006

International Conference on Design and Test of Integrated Systems in Nanoscale Technology, 2006. DTIS 2006.

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“…Recent years have seen growing interest in the automated design and synthesis of microfluidic biochips [11,12,13,14,15,16,17]. One of the first published methods for biochip synthesis decouples high-level synthesis from physical design [11].…”

Section: Related Prior Workmentioning

confidence: 99%

“…These design automation methods address operation scheduling and module placement for digital microfluidics [11,12,13,14,15,16], as well the design and optimization of routing channels in continuous-flow microfluidics [17]. However, none of these tools address the problem of droplet routing in digital microfluidic arrays.…”

Section: Introductionmentioning

confidence: 99%

Integrated droplet routing in the synthesis of microfluidic biochips

Chakrabarty

2007

Proceedings of the 44th Annual Conference on Design Automation - DAC '07

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Microfluidic biochips are revolutionizing many areas of biochemistry and biomedical sciences. Several synthesis tools have recently been proposed for the automated design of biochips from the specifications of laboratory protocols. However, only a few of these tools address the problem of droplet routing in microfluidic arrays. These methods typically rely on post-synthesis droplet routing to implement biochemical protocols. Such an approach is not only time-consuming, but it also imposes an undue burden on the chip user. Moreover, post-synthesis droplet routing does not guarantee that feasible droplet pathways can be found for area-constrained biochip layouts; non-routable fabricated biochips must be discarded. We present a droplet-routing-aware automated synthesis tool for microfluidic biochips. Droplet routability, defined as the ease with which droplet pathways can be determined, is estimated and integrated in the synthesis flow. The proposed approach allows architectural-level design choices and droplet-routing-aware physical design decisions to be made simultaneously. We use a large-scale protein assay as a case study to evaluate the proposed synthesis method.

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“…Recent years have seen growing interest in the automated design and synthesis of microfluidic biochips Hwang et al 2006;Yuh et al 2006;Ricketts 2006;Pfeiffer et al 2006]; see Figure 1. One of the first published methods for biochip synthesis decouples high-level synthesis from physical design [Su and Chakrabarty 2004].…”

Section: Related Prior Workmentioning

confidence: 99%

“…These design automation methods address operation scheduling and module placement for digital microfluidics Hwang et al 2006;Yuh et al 2006;Ricketts et al 2006], as well the design and optimization of routing channels in continuous-flow microfluidics [Pfeiffer et al 2006]. However, only a few of these tools address the problem of droplet routing in digital microfluidic arrays.…”

Section: Introductionmentioning

confidence: 99%

Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips

Chakrabarty

2008

J. Emerg. Technol. Comput. Syst.

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Microfluidic biochips are revolutionizing high-throughput DNA sequencing, immunoassays, and clinical diagnostics. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation techniques is being increasingly felt. Moreover, as most applications of biochips are safety-critical in nature, defect tolerance is an essential system attribute. Several synthesis tools have recently been proposed for the automated design of biochips from the specifications of laboratory protocols. However, only a few of these tools address the problem of defect tolerance. In addition, most of these methods do not consider the problem of droplet routing in microfluidic arrays. These methods typically rely on postsynthesis droplet routing to implement biochemical protocols. Such an approach is not only time consuming, but also imposes an undue burden on the chip user. Postsynthesis droplet routing does not guarantee that feasible droplet pathways can be found for area-constrained biochip layouts; nonroutable fabricated biochips must be discarded. We present a synthesis tool that integrates defect tolerance and droplet routing in the design flow. Droplet routability, defined as the ease with which droplet pathways can be determined, is estimated and integrated in the synthesis procedure. Presynthesis and postsynthesis defect-tolerance methods are also presented. We use a large-scale protein assay as a case study to evaluate the proposed synthesis method.

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Synthesis of Multiplexed Biofluidic Microchips

Cited by 5 publications

References 17 publications

Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Integrated droplet routing in the synthesis of microfluidic biochips

Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips

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