Synthesis of nano curcumin using black pepper oil by O/W Nanoemulsion Technique and investigation of their biological activities

Moghaddasi, Fariba; Housaindokht, Mohammad Reza; Darroudi, Majid; Bozorgmehr, Mohammad Reza; Sadeghi, Akram

doi:10.1016/j.lwt.2018.02.023

Cited by 84 publications

(44 citation statements)

References 31 publications

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“…Interestingly, the anti-proliferative effect was pronounced on HeLa cells, but only in the presence of LE-NEs ( Fig 9A and 9B, Table 7). These results confirm the notion that raw materials' activity can be improved in nanosized formulations, which has been the main drive to produce such formulations [48,50]. The obtained IC50 values on HeLa cells were 153.12 ± 25.66, 152.41 ± 14.62 and 163.72 ± 10.52 μg/ ml, for LE-NE formulations F1, F3 and F4, respectively ( Table 7).…”

Section: Plos Onesupporting

confidence: 81%

“…discoloration of the blue-green ABTS + radical solution [7]. In the DPPH assay, methanol was used to dissolve tested nanoemulsions, assuming that the oil phase was extracted from the nano-droplets [25,41], and the discoloration of the purple DPPH radical solution is proportional to the antioxidant activity of the samples [25,41,48]. Table 6 presents the results of the screening study of the antioxidant activity of the raw materials and nanoemulsions F1 -F4 (composition list presented in Table 2) depending on the sample concentration.…”

Section: Plos Onementioning

confidence: 99%

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Low-energy nanoemulsions as carriers for red raspberry seed oil: Formulation approach based on Raman spectroscopy and textural analysis, physicochemical properties, stability and in vitro antioxidant/ biological activity

et al. 2020

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Considering a growing demand for medicinal/cosmetic products with natural actives, this study focuses on the low-energy nanoemulsions (LE-NEs) prepared via the Phase inversion composition (PIC) method at room temperature as potential carriers for natural oil. Four different red raspberry seed oils (ROs) were tested, as follows: cold-pressed vs. CO 2extracted, organic vs. non-organic, refined vs. unrefined. The oil phase was optimized with Tocopheryl acetate and Isostearyl isostearate, while water phase was adjusted with either glycerol or an antioxidant hydro-glycolic extract. This study has used a combined approach to formulation development, employing both conventional methods (pseudo-ternary phase diagram − PTPD, electrical conductivity, particle size measurements, microscopical analysis, and rheological measurements) and the methods novel to this area, such as textural analysis and Raman spectroscopy. Raman spectroscopy has detected fine differences in chemical composition among ROs, and it detected the interactions within nanoemulsions. It was shown that the cold-pressed, unrefined, organic grade oil (RO2) with 6.62% saturated fatty acids and 92.25% unsaturated fatty acids, was optimal for the LE-NEs. Textural analysis confirmed the existence of cubic gel-like phase as a crucial step in the formation of stable RO2-loaded LE-NEs, with droplets in the narrow nano-range (125 to 135 nm; PDI � 0.1). The DPPH test in methanol and ABTS in aqueous medium have revealed a synergistic free radical scavenging effect between lipophilic and hydrophilic antioxidants in LE-NEs. The nanoemulsion carrier has improved the biological effect of raw materials on HeLa cervical adenocarcinoma cells, while exhibiting good safety profile, as confirmed on MRC-5 normal

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Section: Plos Onesupporting

confidence: 81%

Section: Plos Onementioning

confidence: 99%

Low-energy nanoemulsions as carriers for red raspberry seed oil: Formulation approach based on Raman spectroscopy and textural analysis, physicochemical properties, stability and in vitro antioxidant/ biological activity

et al. 2020

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“…Moghaddasi et al explained the synthesis of the nanocurcumin system (nano-CUR) using the O/W nanoemulsion method. The antioxidant activities of nano-CUR have more potential than its native curcumin and in vitro cytotoxicity effect of nano-CUR was examined in Neuro2A cells suggests that nano-CUR has the potent candidate for the treatment of chronic diseases (Moghaddasi et al, 2018). In another research, Ranjbar et al studied the curcumin and nano-curcumin effects on the oxidant and antioxidant system on the liver mitochondria using aluminum phosphide (AIP) toxicity induced rat model.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

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“…Some physiochemical studies on pepper starch with comparison to other starch will give new application way in near future 81 . Recent research is more focused to the dynamic use of piperine by formulating different dosage forms 82,88,92,93 .…”

Section: Fig 1: Harvested Black Pepper Seeds (L) and Pepper Fruit (mentioning

confidence: 99%

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2018

IJPSR

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Black pepper, the 'King of spices' (Piper nigrum L.), is a widely used spice, known for its pungent odour. From time immemorial, plant sources were used in traditional systems of medicine and day-today common use, such as in meal preparation and cosmetic purposes. This is due to their vast pharmacological potential with minimum side effects. Among the various species of the Piperaceae family, black pepper is one of the most popular due to its principle pharmacological component, piperine. Which is an alkaloid that has diverse pharmacological activities like antioxidant, anti

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Synthesis of nano curcumin using black pepper oil by O/W Nanoemulsion Technique and investigation of their biological activities

Cited by 84 publications

References 31 publications

Low-energy nanoemulsions as carriers for red raspberry seed oil: Formulation approach based on Raman spectroscopy and textural analysis, physicochemical properties, stability and in vitro antioxidant/ biological activity

Low-energy nanoemulsions as carriers for red raspberry seed oil: Formulation approach based on Raman spectroscopy and textural analysis, physicochemical properties, stability and in vitro antioxidant/ biological activity

Nanocurcumin: A Promising Candidate for Therapeutic Applications

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