Synthesis of new 1,2,3‐triazolo[1,5‐a]quinazolinones

Abstract

in Wiley InterScience (www.interscience.wiley.com).Synthesis of novel 3-substituted-1,2,3-triazolo[1,5-a]quinazolinones in high yields was performed via anionic hetero-domino reaction of appropriate substituted 2-azidobenzoates prepared from isatines and acetonitriles activated by 1,3-thiazole, 1,3-benzothiazole, 1,3,4-oxadiazole, and 1,2,4-oxadiazole rings. It was shown that acetonitriles exhibited high reactivity and were convenient methylenic compounds for such reactions providing rapid structural variation.

Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents

“…The 5-amino-1-aryl-1h-1,2,3-triazoles 3-6 and 3h-[1,2,3]triazolo[4,5-b] pyridines 7 derivatives were synthesized earlier at the Department of Organic Chemistry of Ivan Franko National University of Lviv, Ukraine [12,14]. Properties and spectral characteristics of compounds used in this study have been presented in [12,14]. The purity of compounds was established to be higher than 97%, based on liquid chromatography-mass spectrometry examination.…”

“…Various 5-amino-1,2,3-triazoles were obtained by using an efficient synthetic method from the [12,13], 1,3-thiazole [14,15], 1,2,4-/1,3,4-oxadiazole [14], pyrroles and indoles [16] rings and with possible the simultaneous cascade processes leading to polycyclic systems [17,18]. Additionally, the azide [3 + 2] cycloadditions can be performed at room temperature in good to excellent yields of products in the presence of catalytic amounts of pyrrolidine (5-10 mol%) [19,20] according to organocatalytic methodology [21][22][23][24].…”

“…The present work was aimed on evaluation of the anticancer activity of new 5-amino-1-aryl-1h-1,2,3-triazoles scaffolds and their fused derivatives synthesized at 20°C in a short time via azides cyclocondensation, as described [12,14]. The results of performed in vitro study of the anticancer activity of the synthesized compounds towards 60 cancer cell lines suggested the most promising lead candidates with selective influence suitable for further structural optimization.…”

Synthesis, molecular docking and anti-inflammatory activity 2,4-dimethyl-N-(2-aryl)-3-furamides

“…8 In a previous work 9 we have described the synthesis and anti-inflammatory activities of some 2,5-dimethyl-3-furan-3-carboxamides and 5-aryl-2-methyl-3-furan-3-carboxamides. In this article which is the part of our project on of biologically active heterocycles [10][11][12][13][14][15][16][17][18][19][20][21][22][23] we describe synthesis, molecular docking and anti-inflammatory activities of 2,4-dimethyl-N-(2-aryl)-3-furamides.…”

Anticancer activity evaluation of thieno[3,2-e][1,2,3]triazolo[1,5-a]pyrimidines and thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine derivatives

“…Moreover, we previously synthesized several 1,2,3-triazoles which were found to possess significant anticancer activity [10,11]. Recently, we have developed facile synthetic methods for the versatile synthesis of 1,2,3-triazole and thieno-fused compounds, where new efficient and mild procedures from readily available reagents can be employed [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Those protocols could be successfully used for the preparation of fused heterocyclic compounds with both thiophene and 1,2,3-triazole rings.…”