Synthesis of New 2-Substituted Phenyl-1H-Indoles via Fischer Indole Reaction

Abstract

A series of new 2-substituted aryl-1H-indole derivatives have been synthesized by reacting phenyl hydrazine with various substituted acetophenones in presence of sulfuric acid in good to excellent yield. This transformation is based on Fischer indole reaction.

Density and Coefficients of Jones-dole Equation for Viscosity of Ternary Solutions Containing Sucrose/NaCl/KCl in Aqueous Glycine/Urea/Thiourea at 250C

“…The B-coefficients for all the solutes viz. sucrose, NaCl and KCl in aqueous urea solutions are larger than in any other aqueous medium due to more structural organization 17 and relatively strong solute-solvent or ion-solvent interactions in sucrose/ NaCl/KCl+ aqueous urea solutions. The A-coefficient is either negative or positive but very small for all the systems due to weak ion-ion or solute-solute interactions.…”

SBA‐15‐Pr‐SO3H catalyzed one‐pot synthesis of indole derivatives via Fischer indole pathway

“…Also, indole alkaloid marine natural products have attracted lots of attention in the development of new drug leads for the control of cancer, parasitic, and neurological diseases. Among various methods for the preparation of indoles, Fischer indole method has been one of the most powerful approaches [7][8][9][10][11] and a wide spectrum of methodologies based on the efficient catalysts including Brønsted acids (H 2 SO 4 , HCl, PPA, AcOH, and TsOH), Lewis acids (ZnCl 2 , TiCl 4 ), solid acids (zeolite and montmorillonite clay), [12][13][14][15][16][17] heteropolyacids, [18] ionic liquids, [19,20] and ceric ammonium nitrate (CAN) [21] have been reported. Among various methods for the preparation of indoles, Fischer indole method has been one of the most powerful approaches [7][8][9][10][11] and a wide spectrum of methodologies based on the efficient catalysts including Brønsted acids (H 2 SO 4 , HCl, PPA, AcOH, and TsOH), Lewis acids (ZnCl 2 , TiCl 4 ), solid acids (zeolite and montmorillonite clay), [12][13][14][15][16][17] heteropolyacids, [18] ionic liquids, [19,20] and ceric ammonium nitrate (CAN) [21] have been reported.…”

“…[6] In this regard, numerous methods have been developed for the synthesis of indoles and more efficient and straightforward synthetic strategies are still in high demand due to their importance in material sciences and versatile therapeutic applications. Among various methods for the preparation of indoles, Fischer indole method has been one of the most powerful approaches [7][8][9][10][11] and a wide spectrum of methodologies based on the efficient catalysts including Brønsted acids (H 2 SO 4 , HCl, PPA, AcOH, and TsOH), Lewis acids (ZnCl 2 , TiCl 4 ), solid acids (zeolite and montmorillonite clay), [12][13][14][15][16][17] heteropolyacids, [18] ionic liquids, [19,20] and ceric ammonium nitrate (CAN) [21] have been reported.…”

Synthesis and Molecular Docking Based Exploration of Salicylic Acid Derivatives

“…In this method, 5-chloro-2-(1H-indol-2-yl)benzoic acid (3b) was prepared by Shaikh et al method [18]. The mixture of compound 2b (0.01 mol), phenylhydrazene (0.01 mol) and 12 mL of ethanol was refluxed for 2-3 h at 25-30 ºC, cooled at room temperature and poured into 8 mL conc.…”