The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density () and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol·L -1 ) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol·L -1 ) solutions at 30 o C. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability () was calculated from molar refractivity data. Stronger polarizability effects have been observed with increase in drug concentration.
Emerald-green (NH4)4UF8 is the solid phase in equilibrium at 25°with aqueous solutions containing from 24.2 wt. % NH4F to 45.1 wt. % (saturated) NH4F. Its solubility in this range is given in terms of molalities by [U(IV)] = 655[NH4F] "6 + 0.00465 [NH4F] From solutions less concentrated than 24.2 wt. % NH4F, the lower complexes (NH4)2UF6 and 7NH4F'6UF4 are obtained, but (NH4)3UF7 is not observed. (NH4)2UF6 is polymorphic, exhibiting four crystalline modifications near room temperature. The form in equilibrium with NH4F solutions at 25°is orthorhombic 7-(NH4)2UF6, space group Pmc24 or Pmcm, at> = 4.05, bo = 7.03, co -11.76 A., Z -2. The visible spectra of U(IV) in solution show marked changes with the NH4F concentration and some sensitivity to the U(IV) concentration. Fluoride-form anion exchanger absorbs up to 0.60 mole of UF4 per equivalent of exchange capacity.
The density and viscosity of ternary solutions containing Sucrose (non-electrolyte), NaCl and KCl (electrolytes) in aqueous-glycine/urea/thiourea were measured at 25°C. The concentration dependence of viscosity has been studied by Jones-Dole relation and viscosity A and β-coefficients were determined. The comparative account of viscosity β-coefficients for sucrose and salts in different aqueous media has been discussed. The results have been interpreted in terms of different interactions among components of solutions.
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