Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems – A novel class of potential antibacterial, antifungal and antitubercular agents

Mallikarjuna, Bingi Pujari; Sastry, B. S.; Kumar, G.V. Suresh; Rajendraprasad, Y.; Chandrashekar, S.; Sathisha, K.

doi:10.1016/j.ejmech.2009.06.008

Cited by 84 publications

(26 citation statements)

References 23 publications

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“…Derivatives of 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole have been found to possess a wide spectrum of biological activity [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

Ebrahimi

2010

Eur. J. Chem.

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“…Derivatives of 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole have been found to possess a wide spectrum of biological activity [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

Ebrahimi

2010

Eur. J. Chem.

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“…On this basis, a large number of triazole analogues with various structures were further investigated and evaluated for their antimycobacterial activity. [19] Notably, compound 20, [9] with a furan group, could be regarded as a promising lead (MIC = 6.25 mg mL À1 ), whereas compounds 21 [9] and 22, [20] with thiazole groups in their structures, showed moderate to weak activity. agent in the treatment of TB.…”

Section: Triazolesmentioning

confidence: 99%

Recent Advances in the Research of Heterocyclic Compounds as Antitubercular Agents

Yan¹,

Ma²

2012

ChemMedChem

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Tuberculosis (TB) is a major health problem, with approximately one-third of the world's population infected with Mycobacterium tuberculosis, eight million people in the active disease state, and two million dying annually. Furthermore, the prevalence of TB/HIV co-infection, and the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) have further aggravated the spread of this disease and thus mortality by it. There is an urgent need for novel antitubercular agents with improved properties, such as lower toxicity, shortened duration of therapy, rapid bactericidal action, and enhanced activity against MDR strains. Fortunately, a number of new potential antitubercular candidate drugs with heterocyclic rings, which are most likely to be effective against resistant strains, have entered clinical trials in recent years. This review highlights recent advances in the research of novel heterocyclic compounds, with particular focus on their antimycobacterial activity, mechanisms of action, toxicity, and structure-activity relationships (SARs).

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“…A series of 4-isopropylthiazole-2-carbohydrazide analogs, derived from clubbed oxadiazole-thiazole and triazole-thiazole derivatives, have been synthesized and characterized by Mallikarjuna et al [12]. The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal, and antitubercular activity against Mycobacterium tuberculosis H 37 Rv strain by broth dilution assay method.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

Ahamed¹,

Azarudeen²,

Kani³

2014

Bioinorganic Chemistry and Applications

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Terpolymer of 2-amino-6-nitro-benzothiazole-ethylenediamine-formaldehyde (BEF) has been synthesized and characterized by elemental analysis and various spectral techniques like FTIR, UV-Visible, and 1H and 13C-NMR. The terpolymer metal complexes were prepared with Cu2+, Ni2+, and Zn2+ metal ions using BEF terpolymer as a ligand. The complexes have been characterized by elemental analysis and IR, UV-Visible, ESR, 1H-NMR, and 13C-NMR spectral studies. Gel permeation chromatography was used to determine the molecular weight of the ligand. The surface features and crystalline behavior of the ligand and its complexes were analyzed by scanning electron microscope and X-ray diffraction methods. Thermogravimetric analysis was used to analyze the thermal stability of the ligand and its metal complexes. Kinetic parameters such as activation energy (E a) and order of reaction (n) and thermodynamic parameters, namely, ΔS, ΔF, S*, and Z, were calculated using Freeman-Carroll (FC), Sharp-Wentworth (SW), and Phadnis-Deshpande (PD) methods. Thermal degradation model of the terpolymer and its metal complexes was also proposed using PD method. Biological activities of the ligand and its complexes were tested against Shigella sonnei, Escherichia coli, Klebsiella species, Staphylococcus aureus, Bacillus subtilis, and Salmonella typhimurium bacteria and Aspergillus flavus, Aspergillus niger, Penicillium species, Candida albicans, Cryptococcus neoformans, Mucor species fungi.

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Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems – A novel class of potential antibacterial, antifungal and antitubercular agents

Cited by 84 publications

References 23 publications

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

Recent Advances in the Research of Heterocyclic Compounds as Antitubercular Agents

Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains

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