Synthesis of New 7‐Substituted 4‐Methylcoumarin Derivatives of Antimicrobial Activity

Eid, A.; Ragab, F. M.; El-Ansary, Sohair L.; El-Gazayerly, S. M.; Mourad, Fathia E.

doi:10.1002/ardp.19943270404

Cited by 28 publications

(16 citation statements)

References 6 publications

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“…Several simple coumarin derivatives were synthesised from 7-hydroxycoumarin, and derivatives, using a plethora of interesting synthetic strategies [89,113,[191][192][193][194][195][196][197][198][199][200][201][202][203]. Nacetylglucosamides with coumarin aglycones have also been synthesised from 7-hydroxycoumarins [204].…”

Section: From Hydroxy/alkoxycoumarins and Thiocoumarinsmentioning

confidence: 99%

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Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Borges¹,

Roleira²,

Milhazes³

et al. 2005

CMC

890

458

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Coumarins, also known as benzopyrones, are present in remarkable amounts in plants, although their presence has also been detected in microorganisms and animal sources. The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins, such as furocoumarins and pyranocoumarins. Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. Furthermore, they have been reported to have multiple biological activities (anticoagulant, anti-inflammatory), although all these properties have not been evaluated systematically. In addition, their enzyme inhibition properties, antimicrobial and antioxidant activities are other foremost topics of this field of research. The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscoumarins and triscoumarins. Data are also highlighted, concerning the development of new synthetic strategies that could help in drug design and in the work on SAR or QSAR.

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Section: From Hydroxy/alkoxycoumarins and Thiocoumarinsmentioning

confidence: 99%

“…Some coumarins of natural and synthetic origin were screened for their antimicrobial activity [25,69,85,124,180,181,192,236,247,[262][263][264][265][266]. Several coumarin derivatives were also tested for their antifungal activity [195,253].…”

Section: Antiviralmentioning

confidence: 99%

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Borges¹,

Roleira²,

Milhazes³

et al. 2005

CMC

890

458

View full text Add to dashboard Cite

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“…For example, compounds MKT 077(5) and HP-236 (6) have been registered as antitumour and antipsychotic agents while compound 7 and 8 have antimycobacterial activity.…”

Section: -Thiazolidinones 3 and 4 Are The Most Extensively Investigamentioning

confidence: 99%

Progress in the chemistry of 4‐ thiazolidinones

Hamama

Ismail

Shaaban

et al. 2008

Journal of Heterocyclic Chem

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“…Coumarins exhibit a variety of pharmacological activities, such as antiviral [3] and antimicrobial activity. [4] Coumarin 314 (C314, 2,3,5,6-1H,4H-tetrahydro-9-carbethoxyquinolizino-[9,9a,1-gh]coumarin) is a laser dye which exists in two different forms. [5] In the crystalline form, the coumarin moiety is planar, one of the piperidine rings is disordered and the N atom is in a planar configuration.…”

Section: Introductionmentioning

confidence: 99%

The Unusual Fluorescence Quenching of Coumarin 314 by β-Cyclodextrin and the Effect of β-Cyclodextrin on its Binding with Calf Thymus DNA

2014

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This paper discusses the binding of a laser dye, Coumarin 314 with β-cyclodextrin, studied mainly by UV-visible spectroscopy, 2D rotating-frame nuclear Overhauser effect spectroscopy (ROESY), steady-state spectroscopy and time-resolved fluorescence spectroscopy. The role of β-cyclodextrin on the binding of Coumarin 314 with calf thymus DNA was investigated. Coumarin 314 shows a hyperchromic shift of absorption and a quenching of fluorescence due to binding with β-cyclodextrin. The fluorescence quenching is non-linear and the reason for the non-linearity is discussed. The unusual fluorescence quenching on Coumarin 314–β-cyclodextrin binding is rationalised from the effect of acidity on absorption, fluorescence, and molecular modelling studies. Additional proof for the mode of binding is given by 2D ROESY. The capped and exposed portions of the Coumarin 314 molecule in the Coumarin 314–β-cyclodextrin complex when binding with calf thymus DNA were visualised based on spectral and molecular modelling studies.

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Synthesis of New 7‐Substituted 4‐Methylcoumarin Derivatives of Antimicrobial Activity

Abstract: New cyclic derivatives derived from 4-methyl-7-coumarinyloxyacetic acid hydrazide have been synthesized. Some representative examples were screened for antimicrobial activity.

Cited by 28 publications

References 6 publications

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Progress in the chemistry of 4‐ thiazolidinones

The Unusual Fluorescence Quenching of Coumarin 314 by β-Cyclodextrin and the Effect of β-Cyclodextrin on its Binding with Calf Thymus DNA

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