Synthesis of new head‐activator analogues and their application for improved radioimmunoassays

Abstract

New analogues of head activator were produced for receptor and radioimmunoassay studies. The precursor molecules [(4′‐I)Phe11] head activator and [Tyr11] head activator were synthesised for catalytic tritiation and iodination, respectively. With the tracer [(3,5‐125 I2)Tyr11] head activator the sensitivity range of the radioimmunoassay was 5–100 fmol.