Synthesis of new molecularly imprinted polymer via reversible addition fragmentation transfer polymerization as a drug delivery system

Abdollahi, Elaheh; Khalafi-Nezhad, Ali; Mohammadi, Ali; Abdouss, Majid; Salami‐Kalajahi, Mehdi

doi:10.1016/j.polymer.2018.03.058

Cited by 69 publications

(22 citation statements)

References 58 publications

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“…One controlled method for radical polymerization is chain-transfer polymerization. This has been a popular area of growth in polymer science, including examining the potential in other bio-applications [53,54,55]. The chain-transfer agent accurately mediates the growth of the polymer chain, so that the molecular weight can be pre-designed [39,56,57].…”

Section: Contact Lens Materialsmentioning

confidence: 99%

Contact Lens Materials: A Materials Science Perspective

2019

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More is demanded from ophthalmic treatments using contact lenses, which are currently used by over 125 million people around the world. Improving the material of contact lenses (CLs) is a now rapidly evolving discipline. These materials are developing alongside the advances made in related biomaterials for applications such as drug delivery. Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. This review provides an advanced perspective on contact lens materials, with an emphasis on materials science employed in developing new CLs. The future trends for CL materials are to graft, incapsulate, or modify the classic CL material structure to provide new or improved functionality. In this paper, we discuss some of the fundamental material properties, present an outlook from related emerging biomaterials, and provide viewpoints of precision manufacturing in CL development.

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Section: Contact Lens Materialsmentioning

confidence: 99%

Contact Lens Materials: A Materials Science Perspective

2019

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“…To the best of our knowledge, only two examples of polymer N‐grafted DKP have been published. N ‐modified DKPs were used as initiator for reversible addition‐fragmentation polymerization (RAFT) polymerization and as monomer in acyclic diene metathesis (ADMET) polymerization to develop polymers integrating natural and structurally constrained moieties. Amide and carbamate moieties have been shown to be deprotonated with phosphazene bases to initiate the polymerization of epoxide monomers .…”

Section: Introductionmentioning

confidence: 99%

Modification of proline‐based 2,5‐diketopiperazines by anionic ring‐opening polymerization

Tezgel

Puchelle

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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2,5-Diketopiperazines (DKPs) are the smallest cyclic dipeptides found in nature with various attractive properties. In this study, we have demonstrated the successful modification of proline-based DKPs using anionic ring-opening polymerization (AROP) as a direct approach. Four different proline-based DKPs with various side chains and increasing steric hindrance were used as initiating species for the polymerization of 1,2-epoxybutane or ethoxyethyl glycidyl ether in the presence of t-BuP 4 phosphazene base. The addition of a Lewis acid, tri-isobutyl aluminum, to the reaction mixture strongly decreased the occurrence of side reactions. Impact of the DKP side-chain functionalities on molar mass control and dispersity was successfully evidenced.

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“…This immediate release behavior is modified to different extents for nanoparticles with different crosslinker contents and in media with different pH values. Loading the drug into particles alleviates the burst release, since cavities in the cross-linked nanoparticle act as drug storage leading to a timed-release behavior (37,38). The lower amount of cumulative release and reduced immediate release for all nanoparticles at all pH values compared to pure drug confirms this expectation.…”

Section: Drug Loading and Drug Release Studiesmentioning

confidence: 62%

Stimuli-responsive DOX release behavior of cross-linked poly(acrylic acid) nanoparticles

2019

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Cross-linked poly(acrylic acid) nanoparticles were synthesized via distillation precipitation polymerization of acrylic acid and ethylene glycol dimethacrylate withdifferent molar ratios. Spherical nanoparticles with diameters between 75 and 122 nm were synthesized and exhibited temperature and pH-responsive behaviors. However, this behavior was less pronounced for samples with higher cross-linking degrees. The potential of all nanoparticles as carriers for controlled release of doxorubicin (DOX) anti-cancer drug was examined at pH values of 1.2, 5.3 and 7.4. An obvious alleviation in burst release behavior and the amount of cumulative drug release was seen for all nanoparticles as the pH of the medium and the cross-linking degree of nanoparticle increased. Also kinetics of drug release was studied using mathematical models of zero-order, first-order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell, where Higuchi and Korsmeyer-Peppas models best defined the kinetics of drug release.

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Synthesis of new molecularly imprinted polymer via reversible addition fragmentation transfer polymerization as a drug delivery system

Cited by 69 publications

References 58 publications

Contact Lens Materials: A Materials Science Perspective

Contact Lens Materials: A Materials Science Perspective

Modification of proline‐based 2,5‐diketopiperazines by anionic ring‐opening polymerization

Stimuli-responsive DOX release behavior of cross-linked poly(acrylic acid) nanoparticles

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