Synthesis of new oxadiazole, pyrazole and pyrazolin-5-one bearing 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide analogs as potential antibacterial and antifungal agents

Synthesis of 5-heptadecyl- and 5-heptadec-8-enyl substituted 4-amino-1,2,4-triazole-3-thiol and 1,3,4-oxadiazole-2-thione from (Z)-octadec-9-enoic acid: preparation of Palladium(II) complexes and evaluation of their antimicrobial activity

“…Bacteriostatic or bactericide test was determined as follows: a small sample was taken from each well where there was no visible growth, using an inoculation loop, which was then spread on GN plates and incubated overnight at 37°C [36]. The minimum inhibitory concentration (MIC) was the lowest concentration of test compound that inhibit the visible growth of the organism and was determined in triplicates [37]. Table 3.…”

Switching the Enantioselectivities in Michael Addition of Pyrazolin‐5‐Ones to Nitroolefins by Benzoylthiourea Organocatalysts

“…Pyrazolin‐5‐ones, representing an important class of five‐membered‐ring lactams, are common privileged scaffolds in medicinal chemistry and appear in many pharmaceutical agents. For example, Ramana and the co‐workers reported the novel pyrazolin‐5‐one derivatives with very good antibacterial activities; Premnath et al. synthesized the pyrazolin‐5‐one‐based leader with the cytotoxic activity against SiHa cell line; the novel pyrazolin‐5‐one‐based fatty acid elong'ase 6 (ELOVL6) inhibitors were developed by Sato et al.…”