Synthesis of New Schiff's Bases Derived from 4-Phthalimidyl Acetophenone

Abstract

Eight new Schiff's bases were prepared in three steps. The first step includes synthesis of phthalamic acid from the reaction between phthalic anhydride with p-amino acetophenone which in turn fused in the second step to form the corresponding phthalimide. The third step involved condensation of the prepared phthalimide with different primary aromatic amines to form new Schiff's bases. These compounds were characterized by FT-IR, 1 H-NMR and 13 C-NMR spectroscopy. Most of the synthesized compounds have been screened for their antimicrobial activities by using agar cup plate method against two types of bacteria .The results showed that the new Schiff's bases exhibit good to moderate antibacterial activity.

Synthesis of New Some Imidazole Derivatives Containing ?-Lactam Ring

“…Finally, 13 -CNMR spectra of compound (10) showed signal at (8) ppm due to (-3 CH 3 ), signal at (38)ppm due to (-2 CH-), signal at (40) ppm due to C-Cl, signal at (45) ppm due to (-1 CH 2 -), signals at (41) ppm due to (-5 CH-), signals at (117-131)ppm due to aromatic carbons and signals at (170) ppm due to C=O imide [14,15] . Table (5) shows 13 C-NMR spectral data for some of the prepared compounds. 6,7 CH3 and -5 CH-, δ= (2-3) ppm -2 CH-, δ= (3-3.2) ppm -1 CH2-, δ= 4ppm 4 CH-Cl and δ (7-8.6) ppm aromatic protons and NH group 10 δ = 0.9 and 1.6 ppm -3 CH3 and -5 CH-group respectively , δ =(2.2-3) ppm -2 CH-, δ= (3.1-3.9) ppm -1 CH2-, δ= 4ppm 4 CH-Cl , δ =(6.5-8.5) ppm aromatic protons and NH group and δ= 10.1 ppm aromatic OH…”

“…FT-IR spectra were recorded on SHIMADZU FT-IR -8400 Fourier Transform Infrared spectrophotometer as KBR disk. 1 HNMR and 13 CNMR spectra were recorded on Bruker 300MHz, instrument using TMS as internal reference and DMSO-d 6 as a solvent in Jordon.…”

“…13 -CNMRspectra of compound (8) showed signal at(8) ppm due to (-3 CH 3 ), signal at (26) ppm due to (-2 CH-) , signal at (40) ppm due to C-Cl, signal at (45) ppm due to (-1 CH 2 -), signals at (51) ppm due to (-5 CH-), signals at (120-140) ppm due to aromatic carbons and signals at (169) ppm due to C=O imide. 13 -CNMR spectra of compound (9) showed signal at(8) ppm due to (-3 CH 3 ),( 6 CH 3 ) and ( 7 CH 3 ), signal at (25) ppm due to ((-2 CH-), signal at (40) ppm due to C-Cl, signal at (51) ppm due to (-1 CH 2 -), signals at (40.3) ppm due to (-5 CH-), signals at (128-134) ppm due to aromatic carbons and signals at (169) ppm due to C=O imide. Finally, 13 -CNMR spectra of compound (10) showed signal at (8) ppm due to (-3 CH 3 ), signal at (38)ppm due to (-2 CH-), signal at (40) ppm due to C-Cl, signal at (45) ppm due to (-1 CH 2 -), signals at (41) ppm due to (-5 CH-), signals at (117-131)ppm due to aromatic carbons and signals at (170) ppm due to C=O imide [14,15] .…”

“…13 -CNMR spectra of compound (9) showed signal at(8) ppm due to (-3 CH 3 ),( 6 CH 3 ) and ( 7 CH 3 ), signal at (25) ppm due to ((-2 CH-), signal at (40) ppm due to C-Cl, signal at (51) ppm due to (-1 CH 2 -), signals at (40.3) ppm due to (-5 CH-), signals at (128-134) ppm due to aromatic carbons and signals at (169) ppm due to C=O imide. Finally, 13 -CNMR spectra of compound (10) showed signal at (8) ppm due to (-3 CH 3 ), signal at (38)ppm due to (-2 CH-), signal at (40) ppm due to C-Cl, signal at (45) ppm due to (-1 CH 2 -), signals at (41) ppm due to (-5 CH-), signals at (117-131)ppm due to aromatic carbons and signals at (170) ppm due to C=O imide [14,15] . Table (5) shows 13 C-NMR spectral data for some of the prepared compounds.…”

Untitled

“…Synthesis of derivatives 3a-3b [12] These compounds were produced using the procedure described in the literature with some modifications. Compounds 2a-2b (0.01 mol) were dissolved in 20 mL ethanol, followed by the addition of semicarbazide hydrochloride (0.06 mol) and sodium acetate (0.036 mol).…”