Synthesis of New Statin Derivatives

Chioua, Mourad; Marco‐Contelles, José

doi:10.1002/slct.202103544

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In particular, new statins can be synthesized by introducing exogenous synthetic genes into S. cerevisiae. [89,90] However, some challenges still exist to translate bio-statins into practical industrial applications. The expression level of P. pastoris expression system was higher than that of S. cerevisiae expression system, and the cells could be cultured at high density.…”

Section: Challenges and Future Prospectsmentioning

confidence: 99%

Improving statins production: From non‐genetic strategies to genetic strategies

Fan

Tang

Yang

et al. 2023

Biotechnology Journal

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Statins are lipid‐lowering drugs that selectively inhibit 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, effectively reducing cholesterol synthesis. With improved nutritional conditions, the demand for statins is increasing in the global market. The use of microbial cell factories for statin biosynthesis has become advantageous due to the rapid advancements in biotechnology. These approaches offer simple operation and easy separation of products. This review provides an overview the strategies for statins production via microbial cell factories, including both traditional fermentation culture (non‐genetic) and modern synthetic biology manufacture (genetic). Firstly, the complex fermentation parameters and process control technology on submerged fermentation (SmF) and solid‐state fermentation (SSF) are introduced in detail. The potential use of recoverable agricultural wastes/(biomass) as a fermentation substrate in SSF for statin production is emphasized. Additionally, metabolic engineering strategies for constructing robust engineering strains and directed evolution are also discussed. The review highlights the potential and challenges of using microbial cell factories for statin production, and aims to promote greener production modes for statins.This article is protected by copyright. All rights reserved

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Section: Challenges and Future Prospectsmentioning

confidence: 99%

Improving statins production: From non‐genetic strategies to genetic strategies

Fan

Tang

Yang

et al. 2023

Biotechnology Journal

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“…The successful synthesis of simvastatin (Bond and Tang 2019) has demonstrated thatSaccharomyces cerevisiae may be a promising microorganism for the production of statins. In particular, new statins can be synthesized by introducing exogenous synthetic genes into S. cerevisiae (Giugliano, Maiorino et al 2019, Chioua andMarco-Contelles 2021). However, some challenges still exist to translate bio-statins into practical industrial applications.…”

Section: 、、、Challenges and Future Prospectsmentioning

confidence: 99%

Strategies for the statins production in microbial cell factory：present and future

Fan

Tang

Zhao

et al. 2023

Preprint

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Statins as a lipid-lowering drug can selectively inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and decrease cholesterol synthesis effectively. With the improvement of nutritional conditions, the demand for statins is increasing in global market. Due to the rapid development of modern biotechnologies, the biosynthesis of stains by microbial cell factory appears great advantages. It has the advantages of simple operation and easy separation of products. This review summarized the strategies on statins production via microbial cell factory, including both traditional fermentation culture and modern synthetic biology manufacture. Firstly, the complex fermentation parameters and process control technology on submerged fermentation (SmF) and solid-state fermentation (SSF) were introduced in detail. Especially, the possibility of recoverable agricultural wastes/(Biomass) as fermentation substrate on solid-state fermentation to produce statins was emphasized. Besides, metabolic engineering strategies to construct robust engineering strains and strains evolution were also discussed. The review highlights the potential and challenge of microbial cell factory to yield the statins. Thus, it will facilitate the production of statins in more green production mode.

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Optimisation of corn silk tea production, and its antioxidant profile

Wahyudi,

Nisya,

Manshur

et al. 2024

IFRJ

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Following COVID-19 pandemic, functional foods and beverages continue to develop, especially those with high antioxidant activity. The functional beverage from corn silk can be processed into brewed tea. The critical points in the making process of corn silk tea are the drying equipment, drying temperature, and drying time. With efficient method, corn silk tea can produce high antioxidant activity. The present work optimised the temperature and drying method based on antioxidant activity. The results of the present work are expected to be used in micro/small/medium enterprises (MSMEs) to produce corn silk herbal tea. The present work used Randomised Block Design (RBD) with two factors; drying temperatures (45, 55, and 65°C) and drying equipment (cabinet and oven) for 5 h. The analysis carried out was antioxidant activity and profiling using LC-HRMS (liquid chromatography high-resolution mass spectrometry) that ran in a positive (+) mode. The processing of corn silk tea using cabinet drying at 65°C for 5 h produced antioxidant activity of 82.00 ± 0.75%. This was higher than commercial black tea (81.71 ± 0.15%) and commercial green tea (78.37 ± 0.43%). The analysis using LC-HRMS showed that the corn silk tea contained betaine (N,N,N-trimethylglycine) (RT 0.928), 6-methylquinoline (RT 4.741), hesperidin (3’,5,7-trihydroxy-4’-methoxyflavanone) (RT 302.07817), luvangetin (10-methoxy-2,2-dimethylpyrano[3,2-g]chromen-8-one) (RT 258.08837), embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) (RT 13.074), and eucalyptol (1,8-cineole) (RT 13.325).

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Synthesis of New Statin Derivatives

Cited by 3 publications

References 18 publications

Improving statins production: From non‐genetic strategies to genetic strategies

Improving statins production: From non‐genetic strategies to genetic strategies

Strategies for the statins production in microbial cell factory：present and future

Optimisation of corn silk tea production, and its antioxidant profile

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