Synthesis of New Substituted Diamides. Investigation of Their Antioxidant and Antibacterial Properties

Yılmaz, Özgür; Çevik, Pınar Küce; Yılmaz, Mustafa Kemal

doi:10.1134/s1068162021020278

Cited by 2 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, it can be said that the broad-spectrum antimicrobial effect of the p -acetamide molecule originates from the anisole functional groups. Similarly, in many studies, it has been reported that compounds having anisole and amide structures exhibit antibacterial properties against both Gram (+) and Gram (−) bacteria and Mycobacterium tuberculosis bacillus. − …”

Section: Resultsmentioning

confidence: 91%

“…For this reason, studies on the use of natural and synthetic antioxidants as antioxidants are becoming increasingly important today . Amide derivatives have an important place in the fields of medicine, pharmacy, and biology not only with their antimicrobial properties but also because of their antioxidant, anesthetic, and platelet aggregation activities. , …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…16 Amide derivatives have an important place in the fields of medicine, pharmacy, and biology not only with their antimicrobial properties but also because of their antioxidant, anesthetic, and platelet aggregation activities. 26,27 Malki et al investigated the antioxidant activity of five different amide derivatives (benzanilide, dodecanilide, Ncyclohexyloctamide, acetanilide, and acetaminophen (paracetamol)) using the DPPH, FRAP, and β-carotene linoleic acid method, and they determined that these amides showed significant antioxidant activity compared to reference antioxidants. In addition, they determined that the antioxidant effect increased with concentration.…”

Section: Determination Of Antimicrobial Activity Of P-acetamide and M...mentioning

confidence: 99%

See 3 more Smart Citations

First In Vitro–In Silico Analysis for the Determination of Antimicrobial and Antioxidant Properties of 2-(4-Methoxyphenylamino)-2-oxoethyl Methacrylate and p-Acetamide

Temüz,

Çankaya,

Korcan

et al. 2024

ACS Omega

View full text Add to dashboard Cite

The antibacterial, antifungal, and antioxidant activities of 2-chloro-N-(4-methoxyphenyl)acetamide (p-acetamide) and 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) were investigated by in vitro experiments and in silico analyses. MPAEMA has an antibacterial effect only against Gram-positive Staphylococcus aureus. It was determined that this did not affect any other bacteria and Candida glabrata yeast. On the other hand, p-acetamide showed antimicrobial activity against S. aureus ATCC 25923, C. glabrata ATCC 90030, Bacillus subtilis NRRL 744, Enterococcus faecalis ATCC 551289, Escherichia coli ATCC 25922, Klebsiella pneumoniae NRLLB4420, Pseudomonas aeruginosa ATCC 27853, and Listeria monocytogenes ATCC 1911. p-Acetamide showed the greatest antifungal effect by inhibiting the colony growth of Trichoderma longibrachiatum (98%). This was followed by Mucor plumbeus with 83% and Fusarium solani with 21%. MPAEMA inhibited colony growth of T. longibrachiatum by 95% and that of M. plumbeus by 91%. Also, p-acetamide and MPAEMA had a scavenging effect on free radicals. According to results of the in silico analysis, the antimicrobial effect of these compounds is due to their effect on DNA ligase. Based on drug-likeness analysis, they were found to be consistent with the Lipinski, Veber, or Ghose rule. p-Acetamide and MPAEMA may be used as drugs.

show abstract