Synthesis of New Thiobarbituric Acid Derived Spiroheterobicyclic Compounds and Their Antimicrobial Activity

Abstract

A series pf novel (7S, 11R)-substituted diphenyl-2,4,8,10-tetraazaspiro [5.5] undecane-3-thio-1,5,9-triones 4a-j and (7S,11R)-substituted diphenyl-2,4,8,10-tetraazaspiro[5.5] undecane-3-thio-1,5 dione, 9-thiones 5a-j were prepared using substituted aldehydes and urea/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly K-10 clay. The antibacterial potency of these compounds in vitro on the gram negative strains Escherichia coli and Pseudomonas aeruginosa and gram positive strains Staphyllococcus aureus and Staphylococcus epidermidis was evaluated.

Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis‐Amidic Triazole Hybrid Compounds via One‐Pot Sequential Six/Seven Component Ugi‐Click Reaction

“…[1,44] MCR's have also been reported to have applications in the synthesis of hybrid heterocyclic compounds. [45][46][47] In context of our research in the area of multicomponent reactions (MCRs) and synthesis of heterocyclic scaffolds, [48][49][50][51] we tried investigating an efficient multicomponent synthesis of structurally diverse bis(indolyl)methane/ dihydropyrimidinone based hybrid compounds tethered to triazole moiety linked by α-acyl amino amide entity as potential drug like candidates. Besides the in situ auto-catalyzed synthesis of bis(indolyl) methane/dihydropyrimidinone carboxylic acids followed by sequential Ugi and click reactions, the methodology offers a unique approach of six/seven component reaction for the synthesis of multifunctional complex peptidomimetic molecular architecture with three points of diversity.…”