Synthesis of New α-Heterocyclic α-Aminophosphonates

Methyl 2-Benzamido-2-(1H-benzimidazol-1-ylmethoxy)acetate

“…Comparing these results with the work done by our team [12,15,16], we see that we have obtained almost the same results.…”

Synthesis of New Racemic α,α-Diaminocarboxylic Ester Derivatives

“…The literature [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] reports different methods of alkylation, among which phase transfer catalysis, the N -alkylation by microwaves, and the Mitsunobu reaction with organic azides have proved to be efficient key intermediates in organic synthesis for the construction of heterocyclic systems by cycloaddition reactions, while the substitution of the azide group has received much less attention. Continuing our investigations on the use of organic azides [ 50 , 51 ], we report in this paper another part of our investigations concerning the preparation of new α,α-diaminocarboxylic esters derivatives with the aim of providing access to new active biomolecules.…”

Methyl (2R)-2-benzamido-2-{[(1R)-2-methoxy-2-oxo-1-phenylethyl]amino}acetate

“…The synthesis of new -AAs (-aminoacetates) and their esters is of international interest because of their extensive applications in enzymology, medicine, pharmacology and industry (Leite et al, 2006;Mikołajczyk, 2005;Joly et al, 2004). Our strategy used nucleophilic substitution of the N-protected methyl -azido glycinate with 2-amino-2phenylacetate in methylene chloride, in the presence of triethylamine as a base (Boukallaba et al, 2006) to produce the title compound in good yield.…”