Synthesis of Nonwoven Nanofibers by Electrospinning – A Promising Biomaterial for Tissue Engineering and Drug Delivery

Abstract

PHB nanofibers are synthesized by electrospinning of a PHB solution prepared using HFIP as the solvent. The nanofibrous scaffold supports rapid cell growth with normal morphology and attains a viability of 87% after 48 h. Kanamycin sulphate‐loaded PHB nanofiber mats are synthesized, with the antibiotic on the surface and sandwiched within the nanofiber mats: their antimicrobial property is proved by the good zone of inhibition tested against Staphylococcus aureus. The drug shows more than 95% release within 8 h. These results indicate that nanofibers loaded with the antibiotic have potential applications as a template for tissue engineering and as a drug carrier.

Preparation and characterization of electrospun curcumin loaded poly(2-hydroxyethyl methacrylate) nanofiber-A biomaterial for multidrug resistant organisms

“…The polymer solutions were set at a flow rate of 0.5 mL h −1 with the voltage set at 25 kV and at 17‐cm distance from needle tip and the collector. The nanofibers were deposited onto an aluminum substrate wound around a rotary drum placed perpendicular to the needle …”

“…The nanofibers were deposited onto an aluminum substrate wound around a rotary drum placed perpendicular to the needle. 21 Surface morphology studies The electrospun fibers were sputter coated with gold and observed under a scanning electron microscope (FEI Quanta FEG 200-HRSEM) operating at an accelerating voltage of 5-20 kV. TEM (TF 20:Tecnai G2) analysis with an accelerating voltage of 5-20 kV and 200 kV, respectively Diameter of about 50 different fibers were measured using the UTHSCSA image tool to obtain their average diameter.…”

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

“…P(R)-HB [93][94][95][96][97], and bacterial copolymers such as P(3HB-co-4HB) [98][99][100], PHBV [101][102][103] or PHBH and derivatives [104][105][106], have been used for the elaboration of self-assembled systems such as DDSs, tissue engineering scaffolds and implants [107][108][109][110]. Those polymers have been chosen for their biodegradability and biocompatibility.…”

Synthesis of antimicrobial Nisin-phosphorylated soybean protein isolate/poly(l-lactic acid)/ZrO2 membranes

“…Electrospinning, an easy and versatile technique, allows bioactive molecules to be combined with a wide range of additional components and provides a high degree of control over the composition and structure of the produced fibers [6]. Electrospun fibers were widely used in drug delivery [7,8] and wound dressing materials [9,10], attributing to their large surface-to-volume ratio, excellent biocompatibility and biodegradability [11][12][13]. Notably, there has been growing attention to fabricate electrospun fibrous membranes as novel active packaging materials at present [14,15].…”