2013
DOI: 10.1016/j.bmcl.2013.01.021
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Synthesis of novel 2-alkyl triazole-3-alkyl substituted quinoline derivatives and their cytotoxic activity

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Cited by 32 publications
(13 citation statements)
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“…Analogs of the 4-formyl-1,2,3-triazole motif have recently been reported to display enzyme inhibitory, 22 anti-cancer 23,24 antileishmanial 25 and anti-tuberculosis activity. 26,27 With the aldehyde group an attractive handle for synthetic diversification, such compounds have also served as synthons for preparing bioimaging, 28 anti-cancer, 23,24 and antituberculosis 26,27 agents.…”
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confidence: 99%
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“…Analogs of the 4-formyl-1,2,3-triazole motif have recently been reported to display enzyme inhibitory, 22 anti-cancer 23,24 antileishmanial 25 and anti-tuberculosis activity. 26,27 With the aldehyde group an attractive handle for synthetic diversification, such compounds have also served as synthons for preparing bioimaging, 28 anti-cancer, 23,24 and antituberculosis 26,27 agents.…”
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confidence: 99%
“…26,27 With the aldehyde group an attractive handle for synthetic diversification, such compounds have also served as synthons for preparing bioimaging, 28 anti-cancer, 23,24 and antituberculosis 26,27 agents. Likewise, 4-imino-1,2,3-triazoles formed from amine condensation reactions have been shown to be useful for constructing novel coordination compounds.…”
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confidence: 99%
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“…Fused pyrimidine derivatives are extensively used in neurology, particularly in the treatment of neurodegenerative disorders such as Parkinson's disease, 23) antianxiety disorders, 24) and depression. 25) Recent literature also shows that the trifluoromethyl 26,27) group at a strategic position of an organic molecule dramatically alters the properties of the molecule in terms of lipid solubility, oxidative thermal stability thereby enhancing the transport mechanism and bio-efficacy. Similarly, amide derivatives were associated with broad spectrum of biological activities and when amides conjugates with other aliphatic, aromatic and heterocyclic ring produces various type of biological activity.…”
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confidence: 98%
“…Based on the importance of pyrimidine derivatives, encouraged us to synthesize some new highly functionalized substituted pyrido[1,2-a] pyrimidine-3-carboxamide derivatives. In continuation to our efforts, [28][29][30] we designed and synthesized a series of novel trifluoromethyl substituted pyrido[1,2-a] pyrimidine-3-carboxamide derivatives, screened for anti cancer activity against four human cancer cell lines and promising compounds have been identified.…”
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confidence: 99%