Synthesis of Novel 2-Amino-N-hydroxybenzamide Antimicrobials

Abstract

Chemicals were procured from Sigma Aldrich and used as such without further purification. All solvents used for the spectroscopic and other physical studies were reagent grade and were further purified. Melting points were determined using a calibrated thermometer by Guna Digital Melting Point apparatus. They were expressed in degrees centigrade (°C) and are uncorrected. IR spectra were recorded as neat samples on Bruker Alpha-EcoATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared) interferometer with single reflection sampling module equipped with ZnSe crystal and reported in reciprocal centimetres (cm -1 ). 1 H and 13 C NMR spectra were recorded as solutions in DMSO-d 6 on a Bruker AMX 500 MHz spectrometer operating at 400 MHz for 1 H, 100 MHz for 13 C NMR. The 1 H and 13 C chemical shifts were expressed in δ with reference to